S
Sebastien G. M. Uzel
Researcher at Harvard University
Publications - 40
Citations - 2596
Sebastien G. M. Uzel is an academic researcher from Harvard University. The author has contributed to research in topics: Osteogenesis imperfecta & Medicine. The author has an hindex of 17, co-authored 33 publications receiving 1777 citations. Previous affiliations of Sebastien G. M. Uzel include École Normale Supérieure & Wyss Institute for Biologically Inspired Engineering.
Papers
More filters
Journal ArticleDOI
Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels
Mark A. Skylar-Scott,Mark A. Skylar-Scott,Sebastien G. M. Uzel,Sebastien G. M. Uzel,Lucy Nam,Lucy Nam,John H. Ahrens,John H. Ahrens,Ryan L. Truby,Ryan L. Truby,Sarita Damaraju,Sarita Damaraju,Jennifer A. Lewis,Jennifer A. Lewis +13 more
TL;DR: This work reports a biomanufacturing method for assembling hundreds of thousands of stem cell–derived organ building blocks into living matrices with high cellular density into which perfusable vascular channels are introduced via embedded three-dimensional bioprinting.
Journal ArticleDOI
Soft Somatosensitive Actuators via Embedded 3D Printing.
Ryan L. Truby,Michael Wehner,Abigail K. Grosskopf,Daniel M. Vogt,Sebastien G. M. Uzel,Robert J. Wood,Jennifer A. Lewis +6 more
TL;DR: This novel manufacturing approach enables the seamless integration of multiple ionically conductive and fluidic features within elastomeric matrices to produce SSAs with the desired bioinspired sensing and actuation capabilities.
Journal ArticleDOI
Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons.
Tatsuya Osaki,Sebastien G. M. Uzel,Sebastien G. M. Uzel,Sebastien G. M. Uzel,Roger D. Kamm,Roger D. Kamm +5 more
TL;DR: An ALS-on-a-chip technology using three-dimensional skeletal muscle bundles along with induced pluripotent stem cell (iPSC)–derived and light-sensitive channelrhodopsin-2–induced MN spheroids from a patient with sporadic ALS developed, indicating that rapamycin and bosutinib cotreatment has considerable potential for ALS treatment.
Journal ArticleDOI
Microfluidic platforms for mechanobiology
TL;DR: In this paper, the authors discuss how microfluidics has transformed the study of mechanotransduction and discuss new biological insights that have been elucidated by using micro-fluidic experiments.
Journal ArticleDOI
Optogenetic skeletal muscle-powered adaptive biological machines
Ritu Raman,Caroline Cvetkovic,Sebastien G. M. Uzel,Randall Jeffrey Platt,Parijat Sengupta,Roger D. Kamm,Rashid Bashir +6 more
TL;DR: A modular light-controlled skeletal muscle-powered bioactuator that can generate up to 300 µN (0.56 kPa) of active tension force in response to a noninvasive optical stimulus is created, setting the stage for developing multicellular bio-integrated machines and systems for a range of applications.