S
Sébastien Le Jan
Researcher at Collège de France
Publications - 8
Citations - 972
Sébastien Le Jan is an academic researcher from Collège de France. The author has contributed to research in topics: Angiopoietin & Angiopoietin-like 4 Protein. The author has an hindex of 6, co-authored 8 publications receiving 905 citations. Previous affiliations of Sébastien Le Jan include French Institute of Health and Medical Research.
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Journal ArticleDOI
Angiopoietin-Like 4 Is a Proangiogenic Factor Produced during Ischemia and in Conventional Renal Cell Carcinoma
Sébastien Le Jan,Céline Amy,Aurélie Cazes,Catherine Monnot,Noël Lamandé,Judith Favier,Josette Philippe,Mathilde Sibony,Jean-Marie Gasc,Pierre Corvol,Stéphane Germain +10 more
TL;DR: ANGPTL4, originally identified as a peroxisome proliferator-activated receptor alpha and gamma target gene, has potential for use as a new diagnostic tool and a potential therapeutic target, modulating angiogenesis both in tumors and in ischemic tissues.
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Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness
Ariane Galaup,Aurélie Cazes,Sébastien Le Jan,Josette Philippe,Elisabeth Connault,Emmanuelle Le Coz,H. Mekid,Lluis M. Mir,Paule Opolon,Pierre Corvol,Catherine Monnot,Stéphane Germain +11 more
TL;DR: Results show that ANGPTL4, through its action on both vascular and tumor compartments, prevents the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness.
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Extracellular Matrix–Bound Angiopoietin-Like 4 Inhibits Endothelial Cell Adhesion, Migration, and Sprouting and Alters Actin Cytoskeleton
Aurélie Cazes,Ariane Galaup,Clémence Chomel,Marine Bignon,Nicolas Bréchot,Sébastien Le Jan,Holger Weber,Pierre Corvol,Laurent Muller,Stéphane Germain,Catherine Monnot +10 more
TL;DR: It is observed in a mouse model of hindlimb ischemia that the mRNA upregulation in the vessels correlates with the accumulation of the full-length protein in ischemic tissues, which negatively regulates their angiogenic capacities through an autocrine pathway.
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Protection Against Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Angiopoietin-Like 4
Ariane Galaup,Elisa Gomez,Rachid Souktani,Mélanie Durand,Aurélie Cazes,Catherine Monnot,Jérémie Teillon,Sébastien Le Jan,Claire Bouleti,Gaëlle Briois,Josette Philippe,Sandrine Pons,Valérie Martin,Rana Assaly,Philippe Bonnin,Philippe Ratajczak,Anne Janin,Gavin Thurston,David M. Valenzuela,Andrew J. Murphy,George D. Yancopoulos,Renaud Tissier,Alain Berdeaux,Bijan Ghaleh,Stéphane Germain +24 more
TL;DR: The data showed that ANGPTL4 might constitute a relevant target for therapeutic vasculoprotection aimed at counteracting the effects of VEGF, thus being crucial for preventing no-reflow and conferring secondary cardioprotection during AMI.
Journal ArticleDOI
Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer
Sébastien Le Jan,Sébastien Le Jan,Nolwenn Le Meur,Nolwenn Le Meur,Aurélie Cazes,Aurélie Cazes,Josette Philippe,Josette Philippe,Martine Le Cunff,Martine Le Cunff,Jean J. Leger,Jean J. Leger,Pierre Corvol,Pierre Corvol,Stéphane Germain,Stéphane Germain +15 more
TL;DR: These hypoxia‐induced genes could represent relevant prognostic tools and targets for therapeutic intervention in cancers by providing evidence for nrn1 and txnip as hypoxic perinecrotic markers and for igfbp3 as a tumor endothelial marker.