P
Philippe Bonnin
Researcher at University of Paris
Publications - 116
Citations - 4669
Philippe Bonnin is an academic researcher from University of Paris. The author has contributed to research in topics: Ischemia & Hemodynamics. The author has an hindex of 33, co-authored 108 publications receiving 3953 citations. Previous affiliations of Philippe Bonnin include Paris Diderot University & University of the French West Indies and Guiana.
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Journal ArticleDOI
B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction
Yasmine Zouggari,Hafid Ait-Oufella,Hafid Ait-Oufella,Hafid Ait-Oufella,Philippe Bonnin,Tabassome Simon,Andrew P. Sage,Coralie L. Guerin,Coralie L. Guerin,José Vilar,José Vilar,Giuseppina Caligiuri,Dimitrios Tsiantoulas,Dimitrios Tsiantoulas,Ludivine Laurans,Ludivine Laurans,Edouard Dumeau,Edouard Dumeau,Salma Kotti,Patrick Bruneval,Patrick Bruneval,Israel F. Charo,Christoph J. Binder,Christoph J. Binder,Nicolas Danchin,Alain Tedgui,Alain Tedgui,Thomas F. Tedder,Jean-Sébastien Silvestre,Jean-Sébastien Silvestre,Ziad Mallat,Ziad Mallat +31 more
TL;DR: It is shown that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6Chi monocyte mobilization and recruitment to the heart, leading to enhanced tissue injury and deterioration ofMyocardial function.
Journal ArticleDOI
TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice
Yu Wang,Hafid Ait-Oufella,Olivier Herbin,Philippe Bonnin,Bhama Ramkhelawon,Soraya Taleb,Jin Huang,Georges Offenstadt,Christophe Combadière,Laurent Rénia,Jason L. Johnson,Pierre-Louis Tharaux,Alain Tedgui,Ziad Mallat +13 more
TL;DR: A critical role for TGF-beta is identified in the taming of the innate immune response and the preservation of vessel integrity in C57BL/6 mice, which contrasts with its reported pathogenic role in Marfan syndrome.
Journal ArticleDOI
Systemic inflammation disrupts the developmental program of white matter
Géraldine Favrais,Yohan van de Looij,Bobbi Fleiss,Nelina Ramanantsoa,Nelina Ramanantsoa,Philippe Bonnin,Gisela Stoltenburg-Didinger,Adrien Lacaud,Elie Saliba,Olaf Dammann,Olaf Dammann,Olaf Dammann,Jorge Gallego,Jorge Gallego,Stéphane Sizonenko,Henrik Hagberg,Henrik Hagberg,Vincent Lelievre,Pierre Gressens +18 more
TL;DR: The goal of the present study was to test the hypothesis that moderate systemic inflammation is sufficient to alter white matter development.
Journal ArticleDOI
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
Sara Van de Veire,Ingeborg Stalmans,Femke Heindryckx,Hajimu Oura,Annemilaï Tijeras-Raballand,Thomas Schmidt,Sonja Loges,Imke Albrecht,Bart Jonckx,Stefan Vinckier,Christophe Van Steenkiste,Sonia Tugues,Sonia Tugues,Charlotte Rolny,Maria De Mol,Daniela Dettori,Patricia Hainaud,Lieve Coenegrachts,Jean Olivier Contreres,Tine Van Bergen,Henar Cuervo,Wei Hong Xiao,Carole Le Henaff,Ian Buysschaert,Behzad Kharabi Masouleh,Anja Geerts,Tibor Schomber,Philippe Bonnin,Vincent Lambert,Jurgen Haustraete,Serena Zacchigna,Jean-Marie Rakic,Wladimiro Jiménez,Agnès Noël,Mauro Giacca,Isabelle Colle,Jean-Michel Foidart,Gérard Tobelem,Manuel Morales-Ruiz,José Vilar,Patrick H. Maxwell,Stanley A. Vinores,Stanley A. Vinores,Geert Carmeliet,Mieke Dewerchin,Lena Claesson-Welsh,Evelyne Dupuy,Hans Van Vlierberghe,Gerhard Christofori,Massimiliano Mazzone,Michael Detmar,Desire Collen,Peter Carmeliet +52 more
TL;DR: It is shown that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease and warrant further testing of anti-PlGF therapies.
Journal ArticleDOI
Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease
Stéphane M. Camus,João Alfredo Moraes,Philippe Bonnin,Paul Abbyad,Sylvain Le Jeune,François Lionnet,Laurent Loufrani,Linda Grimaud,Jean-Christophe Lambry,Dominique Charue,Laurent Kiger,Jean-Marie Renard,Claire Larroque,Hervé Le Clésiau,Alain Tedgui,Patrick Bruneval,Christina Barja-Fidalgo,Antigoni Alexandrou,Pierre-Louis Tharaux,Chantal M. Boulanger,Olivier Blanc-Brude +20 more
TL;DR: In transgenic SAD mice, infusion of heme-laden MPs triggered rapid vasoocclusions in kidneys and compromised microvascular dilation ex vivo, and may provide new targets for the therapeutic preservation of vascular function in SCD.