S
Sébastien Massier
Researcher at University of Auvergne
Publications - 10
Citations - 467
Sébastien Massier is an academic researcher from University of Auvergne. The author has contributed to research in topics: Intestinal mucosa & Escherichia coli. The author has an hindex of 5, co-authored 10 publications receiving 325 citations. Previous affiliations of Sébastien Massier include French Institute of Health and Medical Research & Institut national de la recherche agronomique.
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Journal ArticleDOI
Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.
Allison Agus,Jérémy Denizot,Jonathan Thévenot,Margarita Martinez-Medina,Sébastien Massier,Pierre Sauvanet,Annick Bernalier-Donadille,Sylvain Denis,Paul Hofman,Richard Bonnet,Elisabeth Billard,Nicolas Barnich +11 more
TL;DR: The results demonstrate that a Western diet could aggravate the inflammatory process and that the activation of the GPR43 receptor pathway could be used as a new strategy to treat CD patients.
Journal ArticleDOI
Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies
TL;DR: The importance of adherent-invasive Escherichia coli as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation is reported.
Journal ArticleDOI
Adaptation of adherent-invasive E. coli to gut environment: Impact on flagellum expression and bacterial colonization ability
Gwladys Sevrin,Sébastien Massier,Benoit Chassaing,Allison Agus,Julien Delmas,Jérémy Denizot,Elisabeth Billard,Nicolas Barnich +7 more
TL;DR: Interestingly, differential flagellin regulation was observed between commensal E. coli (HS) and AIEC (LF82) strains:Flagellum expression by AIEC bacteria, in contrast to that of commensals E.E. coli, is enhanced under intestinal conditions (the presence of bile acids and mucins).
Journal ArticleDOI
Crohn’s Disease-Associated Adherent-Invasive Escherichia coli Manipulate Host Autophagy by Impairing SUMOylation
Guillaume Dalmasso,Guillaume Dalmasso,Hang T T Nguyen,Hang T T Nguyen,Tiphanie Faïs,Tiphanie Faïs,Sébastien Massier,Sébastien Massier,Nicolas Barnich,Nicolas Barnich,Julien Delmas,Julien Delmas,Richard Bonnet,Richard Bonnet +13 more
TL;DR: It is suggested that AIEC inhibits the autophagy response to replicate intracellularly by manipulating host SUMOylation.
Journal ArticleDOI
Ribonucleotide Reductase NrdR as a Novel Regulator for Motility and Chemotaxis during Adherent-Invasive Escherichia coli Infection
Nicolas Dreux,Nicolas Dreux,Maria del Mar Cendra,Sébastien Massier,Sébastien Massier,Arlette Darfeuille-Michaud,Arlette Darfeuille-Michaud,Nicolas Barnich,Nicolas Barnich,Eduard Torrents +9 more
TL;DR: Investigation of the role of RNRs in the virulence of adherent-invasive Escherichia coli isolated from Crohn's disease (CD) patients found that RNR expression was modified in AIEC LF82 bacteria during cell infection, suggesting that R NRs play an important role inAIEC virulence.