S
Seema Mohamed
Researcher at Albany College of Pharmacy and Health Sciences
Publications - 17
Citations - 1399
Seema Mohamed is an academic researcher from Albany College of Pharmacy and Health Sciences. The author has contributed to research in topics: Angiogenesis & Tube formation. The author has an hindex of 12, co-authored 17 publications receiving 1315 citations. Previous affiliations of Seema Mohamed include Wilmington University & DuPont.
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Journal ArticleDOI
Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis.
Joel J. Bergh,Hung Yun Lin,Lawrence Lansing,Seema Mohamed,Faith B. Davis,Shaker A. Mousa,Paul J. Davis,Paul J. Davis +7 more
TL;DR: It is suggested that T(4) binds to alpha(V)beta(3) near the RGD recognition site and show that hormone-binding to alpha (V) beta(3), a cell surface receptor for thyroid hormone, has physiological consequences.
Journal ArticleDOI
Proangiogenic Action of Thyroid Hormone Is Fibroblast Growth Factor–Dependent and Is Initiated at the Cell Surface
Faith B. Davis,Shaker A. Mousa,Laura O’Connor,Seema Mohamed,Hung Yun Lin,H. James Cao,Paul J. Davis +6 more
TL;DR: Thyroid hormone is shown to be a proangiogenic factor, initiated at the plasma membrane, is MAPK dependent and mediated by FGF2.
Journal Article
Novel small molecule alpha v integrin antagonists: comparative anti-cancer efficacy with known angiogenesis inhibitors.
Janet S Kerr,Roseanne S Wexler,Shaker A. Mousa,Robinson Cs,Eric J. Wexler,Seema Mohamed,Voss Me,Devenny Jj,Czerniak Pm,Gudzelak A,Andrew M. Slee +10 more
TL;DR: It is demonstrated that potent selective av antagonist can target endothelial cells, tumor cells, inhibit angiogenesis and inhibit tumor growth and the apoptotic index increased significantly in the SM256 and SG545-treated groups, suggesting increased cell death contributed to decreased tumor volumes.
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Inhibition of endothelial cell tube formation by the low molecular weight heparin, tinzaparin, is mediated by tissue factor pathway inhibitor.
Shaker A. Mousa,Seema Mohamed +1 more
TL;DR: The results suggest that the inhibitory effect of the LMWH tinzaparin on endothelial tube formation is associated with stimulation of the release of TFPI, but not to anti-Factor Xa activity.
Journal ArticleDOI
Anti-angiogenic mechanisms and efficacy of the low molecular weight heparin, tinzaparin: anti-cancer efficacy.
Shaker A. Mousa,Seema Mohamed +1 more
TL;DR: It is demonstrated that tinzaparin is a potent inhibitor of angiogenesis regardless of the angiogenic factor and suggest that its effect is mediated via cellular release of tissue factor pathway inhibitor (TFPI).