Seema Sethi

TL;DR: In this article, a mechanistic understanding of prostate cancer recurrence and metastasis is proposed, which is closely linked with the biology of prostate stem cells or cancer-initiating cells that is reminiscent of the acquisition of Epithelial to Mesenchymal Transition (EMT) phenotype.

TL;DR: The results suggest that the loss of let-7 mediated increased expression of EZH2 contributes to PCa aggressiveness, which could be attenuated by BR-DIM treatment, and thus BR- DIM is likely to have clinical impact.

TL;DR: A role ofmiR-200s in PGI/AMF-induced EMT is suggested and approaches for upregulation of miR- 200s could be a novel therapeutic strategy for the treatment of highly invasive breast cancer.

TL;DR: Variation in the aberrant expression patterns at the invasive tumor front indicates the role of EMT markers in tumor invasion and suggests that Notch-1 could play a role in PCa bone metastasis.

TL;DR: It is shown for the first time that hypoxia leads to increased expression of VEGF, IL-6, and CSC signature genes Nanog, Oct4 and EZH2 consistent with increased cell migration/invasion and angiogenesis, and the formation of pancreatospheres, and thus CDF could become a novel, and effective anti-tumor agent for PC therapy.