Seiji Yamaguchi

TL;DR: This review covers the strategies explored to improve bioactivity, fighting of bacterial infection and biofilm formation, as well as modulation of inflammation of Ti implants since 2010 in the case of Ti and Ti alloys.

TL;DR: In this article, the failure load between implant and bone was measured for treated and untreated plates at 4, 8, 16, and 26 weeks after implantation in rabbit tibia.

TL;DR: The results provide a new principle based on a positively charged surface for obtaining bioactive materials that was obtained when Ti metal was simply heat-treated after a common acid treatment.

TL;DR: Various kinds of novel bioactive materials possessing not only bone-bonding activity and but also various other functions such as bone growth promotion, antibacterial activity and osteoinduction have been developed by systematic research into the apatite formation that occurs on surface-modified Ti metal and its related materials in an acellular simulated body fluid (SBF).

TL;DR: Comparisons of bioactive materials with different surface features to verify the mechanisms of action and the relationship with kinetics and type of precipitated hydroxyapatite over time suggest that the OH groups on the surface have several effects: the total number of theOH groups mainly affects hydrophilicity of surfaces, while the isoelectric points, surface charge and ions attraction mainly depend on OH acidic/basic strength.