S
Seng Lai Tan
Researcher at University of Washington
Publications - 19
Citations - 2697
Seng Lai Tan is an academic researcher from University of Washington. The author has contributed to research in topics: Protein kinase R & Protein kinase A. The author has an hindex of 15, co-authored 17 publications receiving 2649 citations. Previous affiliations of Seng Lai Tan include University of Texas Southwestern Medical Center.
Papers
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Journal ArticleDOI
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
Michael Gale,Marcus J. Korth,Norina M. Tang,Seng Lai Tan,Deborah A. Hopkins,Thomas E. Dever,Stephen J. Polyak,David R. Gretch,Michael G. Katze +8 more
TL;DR: It is reported that NS5A represses PKR through a direct interaction with the protein kinase catalytic domain and that both PKR repression and interaction requires the ISDR, suggesting inactivation of PKR may be one mechanism by which HCV avoids the antiviral effects of IFN.
Journal ArticleDOI
Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation
Michael Gale,Collin M. Blakely,Bart Kwieciszewski,Seng Lai Tan,Michelle L. Dossett,Norina M. Tang,Marcus J. Korth,Stephen J. Polyak,David R. Gretch,Michael G. Katze +9 more
TL;DR: Results indicate that mutations within the PKR-binding region of NS5A, including those within the ISDR, can disrupt the NS5a-PKR interaction, possibly rendering HCV sensitive to the antiviral effects of interferon.
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Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain
Patrick R. Romano,Fan Zhang,Seng Lai Tan,Minerva T. Garcia-Barrio,Michael G. Katze,Thomas E. Dever,Alan G. Hinnebusch +6 more
TL;DR: It is proposed that effective inhibition of PKR in yeast requires formation of an E3-PKR-dsRNA complex, in which the N-terminal half of E3 physically interacts with the protein kinase domain ofPKR.
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Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase
Yupeng He,Haruhisa Nakao,Seng Lai Tan,Stephen J. Polyak,Petra Neddermann,Sangeetha Vijaysri,Bertram L. Jacobs,Michael G. Katze +7 more
TL;DR: A model in which NS5A interacts with Grb2 to inhibit mitogenic signaling while simultaneously promoting the PI3K-AKT cell survival pathway by interaction with p85PI3K is suggested, which may represent a crucial step in HCV persistence and pathogenesis.
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Biochemical and genetic evidence for complex formation between the influenza a virus ns1 protein and the interferon-induced pkr protein kinase
Seng Lai Tan,Michael G. Katze +1 more
TL;DR: The role of NS1 in PKR modulation during viral infection that is mediated through a complex formation between the two proteins is supported, supported by a coprecipitation assay.