S
Senthilkumar K. Muthusamy
Researcher at Central Tuber Crops Research Institute
Publications - 34
Citations - 1028
Senthilkumar K. Muthusamy is an academic researcher from Central Tuber Crops Research Institute. The author has contributed to research in topics: Abiotic stress & Gene. The author has an hindex of 15, co-authored 29 publications receiving 818 citations. Previous affiliations of Senthilkumar K. Muthusamy include Indian Council of Agricultural Research & University of Louisville.
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Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1.
TL;DR: This study suggests a model of post-transcriptional repression, not only of genes involved in oxidative stress regulation and oxidative stress defense proteins, such as Sirt1 and Mgst1, but also of upstream transcription factors regulating their activation.
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Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice.
TL;DR: Down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; this chain event may be a part of the underlying mechanism contributing to the gain in neuronal survival in long-lived CR-fed mice.
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Genome-wide identification and analysis of biotic and abiotic stress regulation of small heat shock protein (HSP20) family genes in bread wheat.
TL;DR: The results illustrate the complexity of the TaHSP20 gene family and its stress regulation in wheat, and suggest that sHSPs as attractive breeding targets for improvement of the heat tolerance of wheat.
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Identification of novel drought-responsive microRNAs and trans-acting siRNAs from Sorghum bicolor (L.) Moench by high-throughput sequencing analysis
Amit Katiyar,Shuchi Smita,Senthilkumar K. Muthusamy,Viswanathan Chinnusamy,Dev Mani Pandey,Kailash C. Bansal +5 more
TL;DR: Genome-wide identification of stress-responsive miRNAs, tasi-RNAs and their targets identified in this study will be useful in unraveling the molecular mechanisms underlying drought stress responses and genetic improvement of biomass production and stress tolerance in sorghum.
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MicroRNA-539 Is Up-regulated in Failing Heart, and Suppresses O-GlcNAcase Expression
Senthilkumar K. Muthusamy,Angelica M. DeMartino,Lewis J. Watson,Kenneth R. Brittian,Ayesha Zafir,Sujith Dassanayaka,Kyung U. Hong,Steven P. Jones +7 more
TL;DR: This work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA, and may represent a novel therapeutic target in the treatment of heart failure and other metabolic diseases.