S
Seong-Kyu Han
Researcher at Chonbuk National University
Publications - 25
Citations - 2448
Seong-Kyu Han is an academic researcher from Chonbuk National University. The author has contributed to research in topics: Gonadotropin-releasing hormone & Neuron. The author has an hindex of 15, co-authored 21 publications receiving 2294 citations. Previous affiliations of Seong-Kyu Han include National Institutes of Health & University of Otago.
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Journal ArticleDOI
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
Seong-Kyu Han,Michelle L. Gottsch,Kathy J Lee,Simina M. Popa,Jeremy Troy Smith,Sonya K Jakawich,Donald K. Clifton,Robert A. Steiner,Allan E. Herbison +8 more
TL;DR: It is demonstrated that kisspeptin exerts a potent depolarizing effect on the excitability of almost all adult GnRH neurons and that the responsiveness of Gn RH neurons tokisspeptin increases over postnatal development.
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Estrogen Receptor β Mediates Rapid Estrogen Actions on Gonadotropin-Releasing Hormone Neurons In Vivo
TL;DR: Observations demonstrate that ERβ mediates the rapid, direct effects of estrogen on the GnRH neuronal phenotype, and that these actions persist under physiological conditions, and provide the first evidence for a role of ERβ in nongenomic estrogen signaling within the brain in vivo.
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Profiling neurotransmitter receptor expression in mouse gonadotropin-releasing hormone neurons using green fluorescent protein-promoter transgenics and microarrays.
TL;DR: The stimulatory actions of GnRH and galanin upon GnRH neurons found here indicate that positive ultrashort feedback loops exist among the GnRH neuronal population and demonstrate a relatively straightforward approach for transcriptome profiling of specific neuronal phenotypes.
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Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse.
TL;DR: GnRH neurons display an unusually late postnatal switch in their response to GABA, and this work provides the first direct evidence that GABA inhibits the electrical activity of postpubertal GnRH neurons.
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Endogenous GABA release inhibits the firing of adult gonadotropin-releasing hormone neurons.
TL;DR: Observations show that endogenous GABA signaling through the GABA(A) receptor exerts a powerful net inhibitory effect upon the excitability of mature GnRH neurons.