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Sergei Kopanchuk
Researcher at University of Tartu
Publications - 42
Citations - 739
Sergei Kopanchuk is an academic researcher from University of Tartu. The author has contributed to research in topics: Receptor & Ligand (biochemistry). The author has an hindex of 12, co-authored 39 publications receiving 504 citations. Previous affiliations of Sergei Kopanchuk include Uppsala University.
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Journal ArticleDOI
Zeta Potential of Extracellular Vesicles: Toward Understanding the Attributes that Determine Colloidal Stability
Getnet Midekessa,Kasun Godakumara,James Ord,Janeli Viil,Freddy Lättekivi,Keerthie Dissanayake,Sergei Kopanchuk,Ago Rinken,Aneta Andronowska,Sourav Bhattacharjee,Toonika Rinken,Alireza Fazeli,Alireza Fazeli +12 more
TL;DR: The integrated data underpins the crucial role of physicochemical attributes that influence the colloidal stability of EVs, and the ZP of EVs became less negative at acidic pH, and vice versa.
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Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide
Pablo Scodeller,Pablo Scodeller,Lorena Simón-Gracia,Sergei Kopanchuk,Allan Tobi,Kalle Kilk,Pille Säälik,Kaarel Kurm,Mario Leonardo Squadrito,Venkata Ramana Kotamraju,Ago Rinken,Michele De Palma,Erkki Ruoslahti,Erkki Ruoslahti,Tambet Teesalu,Tambet Teesalu,Tambet Teesalu +16 more
TL;DR: Applications for UNO peptide in diagnostic imaging and therapeutic targeting of MEMs in solid tumors are suggested and the GSPGAK motif is present in all CD206-binding collagens.
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Co-operative regulation of ligand binding to melanocortin receptor subtypes: evidence for interacting binding sites.
Sergei Kopanchuk,Santa Veiksina,Ramona Petrovska,Ilze Mutule,Michael Szardenings,Ago Rinken,Jarl E. S. Wikberg +6 more
TL;DR: The data indicate that the binding of MSH peptides to melanocortin receptors are governed by a complex dynamic homotropic co-operative regulations.
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Budded baculoviruses as a tool for a homogeneous fluorescence anisotropy-based assay of ligand binding to G protein-coupled receptors: the case of melanocortin 4 receptors.
TL;DR: The FA assay that was developed with budded baculoviruses led the experimental data to a level that would solve complex models of receptor-ligand interactions also for other receptor systems and would become as a valuable tool for the screening of pharmacologically active compounds.
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Tumor-penetrating peptide for systemic targeting of Tenascin-C
Prakash Lingasamy,Allan Tobi,Kaarel Kurm,Sergei Kopanchuk,Aleksander Sudakov,Aleksander Sudakov,Markko Salumäe,Tõnu Rätsep,Toomas Asser,Rolf Bjerkvig,Tambet Teesalu,Tambet Teesalu,Tambet Teesalu +12 more
TL;DR: The systemic tumor-targeting properties and binding of PL3-NPs to the clinical tumor sections, suggest that the PL3 peptide may have applications as a targeting moiety for the selective delivery of imaging and therapeutic agents to solid tumors.