S
Sergio A. Rodriguez-Aponte
Researcher at Massachusetts Institute of Technology
Publications - 19
Citations - 171
Sergio A. Rodriguez-Aponte is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 9 publications receiving 31 citations.
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Journal ArticleDOI
Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.
Neil C. Dalvie,Sergio A. Rodriguez-Aponte,Brittany L. Hartwell,Lisa H. Tostanoski,Andrew M. Biedermann,Laura E. Crowell,Kawaljit Kaur,Ozan S. Kumru,Lauren Carter,Jingyou Yu,Aiquan Chang,Katherine McMahan,Thomas Courant,Celia Lebas,Ashley A. Lemnios,Kristen A Rodrigues,Murillo Silva,Ryan S Johnston,Christopher A Naranjo,Mary Kate Tracey,Joseph R. Brady,Charles A. Whittaker,Dongsoo Yun,Natalie Brunette,Jing Yang Wang,Carl Walkey,Brooke Fiala,Swagata Kar,Maciel Porto,Megan Lok,Hanne Leth Andersen,Mark G. Lewis,Kerry R. Love,Danielle L Camp,Judith M. Silverman,Harry Kleanthous,Sangeeta B. Joshi,David B. Volkin,Patrice M. Dubois,Nicolas Collin,Neil P. King,Dan H. Barouch,Dan H. Barouch,Darrell J. Irvine,Darrell J. Irvine,J. Christopher Love +45 more
TL;DR: In this article, an engineered sequence variant of RBD that exhibits high-yield manufacturability, high-affinity binding to ACE2, and enhanced immunogenicity after a single dose in mice compared to the Wuhan-Hu-1 variant used in current vaccines.
Journal ArticleDOI
SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques
Neil C. Dalvie,Lisa H. Tostanoski,Sergio A. Rodriguez-Aponte,Kawaljit Kaur,S Bajoria,Ozan S. Kumru,Amanda J. Martinot,Abishek Chandrashekar,Katherine McMahan,Noe B. Mercado,Jingyou Yu,Aiquan Chang,Victoria M. Giffin,Felix Nampanya,Shivani A. Patel,Lesley A.H. Bowman,C. A. Naranjo,Dongsoo Yun,Zach Flinchbaugh,Laurent Pessaint,Renita Brown,Jason Velasco,Elyse Teow,Anthony Cook,Hanne Andersen,Mark A. Lewis,Danielle L. Camp,Judith M. Silverman,Gaurav S Nagar,Harish D Rao,Rakesh R. Lothe,Rahul Chandrasekharan,Meghraj P. Rajurkar,Umesh Shaligram,Harry Kleanthous,Sangeeta B. Joshi,David B. Volkin,Sumi Biswas,J. Christopher Love,Dan H. Barouch +39 more
TL;DR: Here, a clinical-stage vaccine candidate comprising a SARS-CoV-2 receptor binding domain–hepatitis B surface antigen virus–like particle elicited protective immunity in cynomolgus macaques, and the potential benefit of this design for a low-cost modular vaccine platform is supported.
Journal ArticleDOI
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity
Brittany L. Hartwell,Mariane B. Melo,Peng Xiao,Ashley A. Lemnios,Na Li,Jason Y. Chang,Jingyou Yu,Makda S. Gebre,Aiquan Chang,Laura Maiorino,Crystal Spruill Carter,Tyson J. Moyer,Neil C. Dalvie,Sergio A. Rodriguez-Aponte,Kristen A. Rodrigues,Murillo Silva,Heikyung Suh,Josetta Adams,Jane Fontenot,J. Christopher Love,Dan H. Barouch,Francois Villinger,Ruth M. Ruprecht,Darrell J. Irvine +23 more
TL;DR: It is suggested that using amph-protein vaccines to deliver antigen across mucosal epithelia is a promising strategy to promote mucosal immunity against HIV, SARS-CoV-2, and other infectious diseases.
Posted ContentDOI
Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters
Neil C. Dalvie,Sergio A. Rodriguez-Aponte,Brittany L. Hartwell,Lisa H. Tostanoski,Andrew M. Biedermann,Laura E. Crowell,Kawaljit Kaur,Ozan S. Kumru,Lauren Carter,Jingyou Yu,Aiquan Chang,Aiquan Chang,Katherine McMahan,Thomas Courant,Celia Lebas,Ashley A. Lemnios,Kristen A Rodrigues,Kristen A Rodrigues,Murillo Silva,Ryan S Johnston,Christopher A Naranjo,Mary Kate Tracey,Joseph R. Brady,Charles A. Whittaker,Dongsoo Yun,Swagata Kar,Maciel Porto,Megan Lok,Hanne Leth Andersen,Mark G. Lewis,Kerry R. Love,Danielle L Camp,Judith M. Silverman,Harry Kleanthous,Sangeeta B. Joshi,David B. Volkin,Patrice M. Dubois,Nicolas Collin,Neil P. King,Dan H. Barouch,Darrell J. Irvine,J. Christopher Love +41 more
TL;DR: In this article, an engineered sequence variant of RBD that exhibits high-yield manufacturability, high-affinity binding to ACE2, and enhanced immunogenicity after a single dose in mice compared to the Wuhan-Hu-1 variant used in current vaccines.
Posted ContentDOI
Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii
Neil C. Dalvie,Andrew M. Biedermann,Sergio A. Rodriguez-Aponte,Christopher A Naranjo,Harish D Rao,Meghraj P Rajurkar,Rakesh R Lothe,Umesh Shaligram,Ryan S Johnston,Laura E. Crowell,Seraphin Castelino,Mary Kate Tracey,Charles A. Whittaker,J. Christopher Love +13 more
TL;DR: In this article, an improved and scalable manufacturing approach for the SARS-CoV-2 spike protein receptor binding domain (RBD) was reported, which is a key antigen for several reported vaccine candidates.