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Abishek Chandrashekar
Researcher at Beth Israel Deaconess Medical Center
Publications - 76
Citations - 8469
Abishek Chandrashekar is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Vaccination & Medicine. The author has an hindex of 20, co-authored 52 publications receiving 4712 citations. Previous affiliations of Abishek Chandrashekar include Northeastern University.
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Journal ArticleDOI
DNA vaccine protection against SARS-CoV-2 in rhesus macaques.
Jingyou Yu,Lisa H. Tostanoski,Lauren Peter,Noe B. Mercado,Katherine McMahan,Shant H. Mahrokhian,Joseph P. Nkolola,Jinyan Liu,Zhenfeng Li,Abishek Chandrashekar,David R. Martinez,Carolin Loos,Caroline Atyeo,Stephanie Fischinger,John S. Burke,Matthew D. Slein,Yuezhou Chen,Adam Zuiani,Felipe J.N. Lelis,Meghan Travers,Shaghayegh Habibi,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Renita Brown,Anthony Cook,Brad Finneyfrock,Alan Dodson,Elyse Teow,Jason Velasco,Roland Zahn,Frank Wegmann,Esther A. Bondzie,Gabriel Dagotto,Makda S. Gebre,Xuan He,Catherine Jacob-Dolan,Marinela Kirilova,Nicole Kordana,Zijin Lin,Lori F. Maxfield,Felix Nampanya,Ramya Nityanandam,John D. Ventura,Huahua Wan,Yongfei Cai,Bing Chen,Aaron G. Schmidt,Duane R. Wesemann,Ralph S. Baric,Galit Alter,Hanne Andersen,Mark G. Lewis,Dan H. Barouch,Dan H. Barouch +54 more
TL;DR: Analysis of the vaccine candidates in rhesus macaques showed that animals developed protective humoral and cellular immune responses when challenged with the SARS-CoV-2 virus, suggesting an immune correlate of protection.
Journal ArticleDOI
Correlates of protection against SARS-CoV-2 in rhesus macaques.
Katherine McMahan,Jingyou Yu,Noe B. Mercado,Carolin Loos,Carolin Loos,Lisa H. Tostanoski,Abishek Chandrashekar,Jinyan Liu,Lauren Peter,Caroline Atyeo,Caroline Atyeo,Alex Lee Zhu,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Zhenfeng Li,Felix Nampanya,Shivani A. Patel,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Jake Yalley-Ogunro,Mehtap Cabus,Renita Brown,Anthony L. Cook,Elyse Teow,Hanne Andersen,Mark G. Lewis,Douglas A. Lauffenburger,Galit Alter,Dan H. Barouch +34 more
TL;DR: It is demonstrated that relatively low antibody titers are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may also contribute to protection if antibody responses are suboptimal.
Journal ArticleDOI
Potently neutralizing and protective human antibodies against SARS-CoV-2.
Seth J. Zost,Pavlo Gilchuk,James Brett Case,Elad Binshtein,Rita E. Chen,Joseph P. Nkolola,Alexandra Schäfer,Joseph X. Reidy,Andrew Trivette,Rachel S. Nargi,Rachel E. Sutton,Naveenchandra Suryadevara,David R. Martinez,Lauren E. Williamson,Elaine C. Chen,Taylor Jones,Samuel Day,Luke Myers,Ahmed O. Hassan,Natasha M. Kafai,Emma S. Winkler,Julie M. Fox,Swathi Shrihari,Benjamin K. Mueller,Jens Meiler,Jens Meiler,Abishek Chandrashekar,Noe B. Mercado,James J. Steinhardt,Kuishu Ren,Yueh-Ming Loo,Nicole L. Kallewaard,Broc T. McCune,Shamus P. Keeler,Michael J. Holtzman,Dan H. Barouch,Lisa E. Gralinski,Ralph S. Baric,Larissa B. Thackray,Michael S. Diamond,Robert H. Carnahan,James E. Crowe +41 more
TL;DR: An analysis identifies human monoclonal antibodies that potently neutralize wild-type SARS-CoV-2 and protect animals from disease, including two that synergize in a cocktail, suggesting that these could be candidates for use as therapeutic agents for the treatment of COVID-19 in humans.
Journal ArticleDOI
SARS-CoV-2 infection protects against rechallenge in rhesus macaques.
Abishek Chandrashekar,Jinyan Liu,Amanda J. Martinot,Amanda J. Martinot,Katherine McMahan,Noe B. Mercado,Lauren Peter,Lisa H. Tostanoski,Jingyou Yu,Zoltan Maliga,Michael Nekorchuk,Kathleen Busman-Sahay,Margaret Terry,Linda M. Wrijil,Sarah Ducat,David R. Martinez,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,John S. Burke,Matthew D. Slein,Laurent Pessaint,Alex Van Ry,Jack Greenhouse,Tammy Taylor,Kelvin Blade,Anthony Cook,Brad Finneyfrock,Renita Brown,Elyse Teow,Jason Velasco,Roland Zahn,Frank Wegmann,Peter Abbink,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Xuan He,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Nicole Kordana,Zhenfeng Li,Michelle A. Lifton,Shant H. Mahrokhian,Lori F. Maxfield,Ramya Nityanandam,Joseph P. Nkolola,Aaron G. Schmidt,Andrew D. Miller,Ralph S. Baric,Galit Alter,Peter K. Sorger,Jacob D. Estes,Hanne Andersen,Mark G. Lewis,Dan H. Barouch,Dan H. Barouch +58 more
TL;DR: Data show that SARS-CoV-2 infection induced protective immunity against reexposure in nonhuman primates, and these findings have key implications for public health and economic initiatives if validated in human studies.
Journal ArticleDOI
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
Noe B. Mercado,Roland Zahn,Frank Wegmann,Carolin Loos,Carolin Loos,Abishek Chandrashekar,Jingyou Yu,Jinyan Liu,Lauren Peter,Katherine McMahan,Lisa H. Tostanoski,Xuan He,David R. Martinez,Lucy Rutten,Rinke Bos,Danielle van Manen,Jort Vellinga,Jerome Custers,Johannes P. M. Langedijk,Ted Kwaks,Mark J. G. Bakkers,David Zuijdgeest,Sietske K. Rosendahl Huber,Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,John S. Burke,Jared Feldman,Jared Feldman,Blake M. Hauser,Blake M. Hauser,Timothy M. Caradonna,Timothy M. Caradonna,Esther A. Bondzie,Gabriel Dagotto,Gabriel Dagotto,Makda S. Gebre,Makda S. Gebre,Emily Hoffman,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Marinela Kirilova,Zhenfeng Li,Zijin Lin,Shant H. Mahrokhian,Lori F. Maxfield,Felix Nampanya,Ramya Nityanandam,Joseph P. Nkolola,Shivani A. Patel,John D. Ventura,Kaylee Verrington,Huahua Wan,Laurent Pessaint,Alex Van Ry,Kelvin Blade,Amanda Strasbaugh,Mehtap Cabus,Renita Brown,Anthony L. Cook,Serge Zouantchangadou,Elyse Teow,Hanne Andersen,Mark G. Lewis,Yongfei Cai,Bing Chen,Aaron G. Schmidt,Aaron G. Schmidt,R. Keith Reeves,Ralph S. Baric,Douglas A. Lauffenburger,Galit Alter,Paul Stoffels,Mathai Mammen,Johan Van Hoof,Hanneke Schuitemaker,Dan H. Barouch +77 more
TL;DR: Robust single-shot vaccine protection against SARS-CoV-2 in nonhuman primates is demonstrated and vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection.