1. Type 1 diabetes (due to b-cell destruction, usually leading to absolute insulin deficiency) 2. Type 2 diabetes (due to a progressive insulin secretory defect on the background of insulin resistance) 3. Gestational diabetes mellitus (GDM) (diabetes diagnosed in the second or third trimester of pregnancy that is not clearly overt diabetes) 4. Specific types of diabetes due to other causes, e.g., monogenic diabetes syndromes (such as neonatal diabetes and maturity-onset diabetes of the young [MODY]), diseases of the exocrine pancreas (such as cystic fibrosis), and drugor chemical-induced diabetes (such as in the treatment of HIV/AIDS or after organ transplantation)

Classification and diagnosis of diabetes

https://uhra.herts.ac.uk/bitstream/handle/2299/11214/904970.pdf;sequence=2

A review of solar collectors and thermal energy storage in solar thermal applications

This article reviews acoustic microfiuidics: the use of acoustic fields, principally ultrasonics, for application in microfiuidics. Although acoustics is a classical field, its promising, and indeed perplexing, capabilities in powerfully manipulating both fluids and particles within those fluids on the microscale to nanoscale has revived interest in it. The bewildering state of the literature and ample jargon from decades of research is reorganized and presented in the context of models derived from first principles. This hopefully will make the area accessible for researchers with experience in materials science, fluid mechanics, or dynamics. The abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques common in microfluidics, along with the many applications in microfluidics and nanofluidics that appear through the literature.

/pdf/microscale-acoustofluidics-microfluidics-driven-via-5bet39j13p.pdf

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clinical management of breast cancer relies on the availability of robust clinical and pathological prognostic and predictive factors to support clinical and patient decision making in which potentially suitable treatment options are increasingly available. One of the best-established prognostic factors in breast cancer is histological grade, which represents the morphological assessment of tumor biological characteristics and has been shown to be able to generate important information related to the clinical behavior of breast cancers. Genome-wide microarray-based expression profiling studies have unraveled several characteristics of breast cancer biology and have provided further evidence that the biological features captured by histological grade are important in determining tumor behavior. Also, expression profiling studies have generated clinically useful data that have significantly improved our understanding of the biology of breast cancer, and these studies are undergoing evaluation as improved prognostic and predictive tools in clinical practice. Clinical acceptance of these molecular assays will require them to be more than expensive surrogates of established traditional factors such as histological grade. It is essential that they provide additional prognostic or predictive information above and beyond that offered by current parameters. Here, we present an analysis of the validity of histological grade as a prognostic factor and a consensus view on the significance of histological grade and its role in breast cancer classification and staging systems in this era of emerging clinical use of molecular classifiers.

Breast cancer prognostic classification in the molecular era: the role of histological grade

Entropy generation in steady MHD flow due to a rotating porous disk in a nanofluid

Minimization of entropy generation by asymmetric convective cooling

Entropy generation minimization of a MHD (magnetohydrodynamic) flow in a microchannel

This paper analyses numerically the quasi-two-dimensional flow of an incompressible electrically conducting viscous fluid past a localized zone of applied magnetic field, denominated a magnetic obstacle. The applied field is produced by the superposition of two parallel magnetized square surfaces, uniformly polarized in the normal direction, embedded in the insulating walls that contain the flow. The area of these surfaces is only a small fraction of the total flow domain. By considering inertial effects in the analysis under the low magnetic Reynolds number approximation, it is shown that the flow past a magnetic obstacle may develop vortical structures and eventually instabilities similar to those observed in flows interacting with bluff bodies. In the small zone where the oncoming uniform flow encounters the non-negligible magnetic field, the induced electric currents interact with the field, producing a non-uniform Lorentz force that brakes the fluid and creates vorticity. The effect of boundary layers is introduced through a friction term. Due to the localization of the applied magnetic field, this term models either the Hartmann braking within the zone of high magnetic field strength or a Rayleigh friction in zones where the magnetic field is negligible. Finite difference numerical computations have been conducted for Reynolds numbers Re=100 and 200, and Hartmann numbers in the range 1 ≤ Ha ≤ 100 (Re and Ha are based on the side length of the magnetized square surfaces). Under these conditions, a wake is formed behind the obstacle. It may display two elongated streamwise vortices that remain steady as long as the Hartmann number does not exceed a critical value. Once this value is reached, the wake becomes unstable and a vortex shedding process similar to the one observed in the flow past bluff bodies is established. Similarities and differences with the flow around solid obstacles are discussed.

On the flow past a magnetic obstacle

In this paper, the consequences of considering fluid/wall slippage in magnetohydrodynamic (MHD) micropumps are explored by analytical and numerical calculations. One- and two-dimensional flow models commonly used to describe MHD micropumps, are revisited by assuming the slip condition in low-Hartmann-number flows. Different combinations of slip and no slip conditions at the walls of the micropump are investigated, and the influence of the slip length on the flow rate is analyzed.

Analysis of the slip condition in magnetohydrodynamic (MHD) micropumps

Aberrant DNA methylation is a frequent epigenetic alteration in cancer cells that has emerged as a pivotal mechanism for tumorigenesis. Accordingly, novel therapies targeting the epigenome are being explored with the aim to restore normal DNA methylation patterns on oncogenes and tumor suppressor genes. A limited number of studies indicate that dietary compound resveratrol modulates DNA methylation of several cancer-related genes; however a complete view of changes in methylome by resveratrol has not been reported yet. In this study we performed a genome-wide survey of DNA methylation signatures in triple negative breast cancer cells exposed to resveratrol. Our data showed that resveratrol treatment for 24 h and 48 h decreased gene promoter hypermethylation and increased DNA hypomethylation. Of 2476 hypermethylated genes in control cells, 1,459 and 1,547 were differentially hypomethylated after 24 h and 48 h, respectively. Remarkably, resveratrol did not induce widespread non-specific DNA hyper- or hypomethylation as changes in methylation were found in only 12.5% of 27,728 CpG loci. Moreover, resveratrol restores the hypomethylated and hypermethylated status of key tumor suppressor genes and oncogenes, respectively. Importantly, the integrative analysis of methylome and transcriptome profiles in response to resveratrol showed that methylation alterations were concordant with changes in mRNA expression. Our findings reveal for the first time the impact of resveratrol on the methylome of breast cancer cells and identify novel potential targets for epigenetic therapy. We propose that resveratrol may be considered as a dietary epidrug as it may exert its anti-tumor activities by modifying the methylation status of cancer -related genes which deserves further in vivo characterization.

/pdf/methylation-landscape-of-human-breast-cancer-cells-in-207eimy46n.pdf

Sergio Cuevas

Papers

Minimization of entropy generation by asymmetric convective cooling

Entropy generation minimization of a MHD (magnetohydrodynamic) flow in a microchannel

On the flow past a magnetic obstacle

Analysis of the slip condition in magnetohydrodynamic (MHD) micropumps

Methylation landscape of human breast cancer cells in response to dietary compound resveratrol