抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Preliminary reference earth model

A digital bathymetric map of the oceans with a horizontal resolution of 1 to 12 kilometers was derived by combining available depth soundings with high-resolution marine gravity information from the Geosat and ERS-1 spacecraft. Previous global bathymetric maps lacked features such as the 1600-kilometer-long Foundation Seamounts chain in the South Pacific. This map shows relations among the distributions of depth, sea floor area, and sea floor age that do not fit the predictions of deterministic models of subsidence due to lithosphere cooling but may be explained by a stochastic model in which randomly distributed reheating events warm the lithosphere and raise the ocean floor.

Global Sea Floor Topography from Satellite Altimetry and Ship Depth Soundings

This essential reference for graduate students and researchers provides a unified treatment of earthquakes and faulting as two aspects of brittle tectonics at different timescales. The intimate connection between the two is manifested in their scaling laws and populations, which evolve from fracture growth and interactions between fractures. The connection between faults and the seismicity generated is governed by the rate and state dependent friction laws - producing distinctive seismic styles of faulting and a gamut of earthquake phenomena including aftershocks, afterslip, earthquake triggering, and slow slip events. The third edition of this classic treatise presents a wealth of new topics and new observations. These include slow earthquake phenomena; friction of phyllosilicates, and at high sliding velocities; fault structures; relative roles of strong and seismogenic versus weak and creeping faults; dynamic triggering of earthquakes; oceanic earthquakes; megathrust earthquakes in subduction zones; deep earthquakes; and new observations of earthquake precursory phenomena.

The Mechanics of Earthquakes and Faulting

A global plate motion model, named NUVEL-1, which describes current plate motions between 12 rigid plates is described, with special attention given to the method, data, and assumptions used Tectonic implications of the patterns that emerged from the results are discussed It is shown that wide plate boundary zones can form not only within the continental lithosphere but also within the oceanic lithosphere; eg, between the Indian and Australian plates and between the North American and South American plates Results of the model also suggest small but significant diffuse deformation of the oceanic lithosphere, which may be confined to small awkwardly shaped salients of major plates

Current plate motions

Recent revisions to the geomagnetic time scale indicate that global plate motion model NUVEL-1 should be modified for comparison with other rates of motion including those estimated from space geodetic measurements. The optimal recalibration, which is a compromise among slightly different calibrations appropriate for slow, medium, and fast rates of seafloor spreading, is to multiply NUVEL-1 angular velocities by a constant, α, of 0.9562. We refer to this simply recalibrated plate motion model as NUVEL-1A, and give correspondingly revised tables of angular velocities and uncertainties. Published work indicates that space geodetic rates are slower on average than those calculated from NUVEL-1 by 6±1%. This average discrepancy is reduced to less than 2% when space geodetic rates are instead compared with NUVEL-1A.

https://agupubs.onlinelibrary.wiley.com/doi/pdf/10.1029/94GL02118%4010.1002/%28ISSN%291944-8007.GRL40

Effect of recent revisions to the geomagnetic reversal time scale on estimates of current plate motions

SUMMARY 
We determine best-fitting Euler vectors, closure-fitting Euler vectors, and a new global model (NUVEL-1) describing the geologically current motion between 12 assumed-rigid plates by inverting plate motion data we have compiled, critically analysed, and tested for self-consistency. We treat Arabia, India and Australia, and North America and South America as distinct plates, but combine Nubia and Somalia into a single African plate because motion between them could not be reliably resolved. The 1122 data from 22 plate boundaries inverted to obtain NUVEL-1 consist of 277 spreading rates, 121 transform fault azimuths, and 724 earthquake slip vectors. We determined all rates over a uniform time interval of 3.0m.y., corresponding to the centre of the anomaly 2A sequence, by comparing synthetic magnetic anomalies with observed profiles. The model fits the data well. Unlike prior global plate motion models, which systematically misfit some spreading rates in the Indian Ocean by 8–12mm yr−1, the systematic misfits by NUVEL-1 nowhere exceed ∼3 mm yr−1. The model differs significantly from prior global plate motion models. For the 30 pairs of plates sharing a common boundary, 29 of 30 P071, and 25 of 30 RM2 Euler vectors lie outside the 99 per cent confidence limits of NUVEL-1. Differences are large in the Indian Ocean where NUVEL-1 plate motion data and plate geometry differ from those used in prior studies and in the Pacific Ocean where NUVEL-1 rates are systematically 5–20 mm yr−1 slower than those of prior models. The strikes of transform faults mapped with GLORIA and Seabeam along the Mid-Atlantic Ridge greatly improve the accuracy of estimates of the direction of plate motion. These data give Euler vectors differing significantly from those of prior studies, show that motion about the Azores triple junction is consistent with plate circuit closure, and better resolve motion between North America and South America. Motion of the Caribbean plate relative to North or South America is about 7 mm yr−1 slower than in prior global models. Trench slip vectors tend to be systematically misfit wherever convergence is oblique, and best-fitting poles determined only from trench slip vectors differ significantly from their corresponding closure-fitting Euler vectors. The direction of slip in trench earthquakes tends to be between the direction of plate motion and the normal to the trench strike. Part of this bias may be due to the neglect of lateral heterogeneities of seismic velocities caused by cold subducting slabs, but the larger part is likely caused by independent motion of fore-arc crust and lithosphere relative to the overriding plate.

Variations in sea-floor depth and heat flow with age provide the main constraints on the thermal structure and evolution of the oceanic lithosphere. Joint fitting of heat flow and bathymetry yields a model with a hotter, thinner lithosphere than in previous models. The new model provides a significantly better fit to the data, including those from older lithosphere previously treated as anomalous. This will facilitate the analysis of lithospheric processes, including the effects of mid-plate volcanism and swells, regional subsidence, and hydrothermal circulation near spreading centers.

A model for the global variation in oceanic depth and heat flow with lithospheric age

We investigate angular velocity vectors of the Philippine Sea (PH) plate relative to the adjacent major plates, Eurasia (EU) and Pacific (PA), and the smaller Caroline (CR) plate. Earthquake slip vector data along the Philippine Sea plate are inverted, subject to the constraint that EU-PA motion equals that predicted by the global relative plate model NUVEL-1. The resulting solution fails to satisfy geological constraints along the Caroline-Pacific boundary: convergence along the Mussau Trench and divergence along the Sorol Trough. We then seek solutions satisfying both the CR-PA boundary conditions and the Philippine Sea slip vector data, by adjusting the PA-PH and EU-PH best fitting poles within their error ellipses. We also consider northern Honshu to be part of the North American plate and impose the constraint that the Philippine Sea plate subducts beneath northern Honshu along the Sagmi Trough in a NNW-NW direction. Of the solutions satisfying these conditions, we select the best EU-PH as 48.2 deg N, 157.0 deg E, 1.09 deg/my, corresponding to a pole far from Japan and south of Kamchatka, and PA-PH, 1.2 deg N, 134.2 deg E, 1.00 deg/my. Predicted NA-PH and EU-PH convergence rates in central Honshu are consistent with estimated seismic slip rates. Previous estimates of the EU-PH pole close to central Honshu are inconsistent with extension within the Bonin backarc implied by earthquake slip vectors and NNW-NW convergence of the Bonin forearc at the Sagami Trough.

Seth Stein

Papers

Current plate motions

Effect of recent revisions to the geomagnetic reversal time scale on estimates of current plate motions

Current plate motions

A model for the global variation in oceanic depth and heat flow with lithospheric age

A model for the motion of the Philippine Sea Plate consistent with NUVEL‐1 and geological data