抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

Evolution of Protein Molecules

Statistical Analysis with Missing Data

This text, drawn from the author's lectures at the University of California at Berkeley, is intended as a textbook for a one-term course in basic ring theory. The material covered includes the Wedderburn-Artin theory of semi-simple rings, Jacobson's theory of the radical representation theory of groups and algebras, prime and semi-prime rings, primitive and semi-primitive rings, division rings, ordered rings, local and semi-local rings, and perfect and semi-perfect rings. By aiming the level of writing at the novice rather than at the expert, and by stressing the role of examples and motivation, the author has produced a text which is suitable not only for use in a graduate course, but also for self-study by other interested graduate students. Numerous exercises are also included. This graduate textbook on rings, fields and algebras is intended for graduate students in mathematics.

A first course in noncommutative rings, by T. Y. Lam. Pp. 385. £37 (pb), £62.50 (hb). 2001. ISBN 0 387 95325 6 (pb), 0 387 95183 0 (hb) (Springer-Verlag).

Markov Bases.- Likelihood Inference.- Conditional Independence.- Hidden Variables.- Bayesian Integrals.- Exercises.- Open Problems.

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Lectures on Algebraic Statistics

Statistical models of evolution are algebraic varieties in the space of joint probability distributions on the leaf colorations of a phylogenetic tree. The phylogenetic invariants of a model are the polynomials which vanish on the variety. Several widely used models for biological sequences have transition matrices that can be diagonalized by means of the Fourier transform of an Abelian group. Their phylogenetic invariants form a toric ideal in the Fourier coordinates. We determine generators and Grobner bases for these toric ideals. For the Jukes–Cantor and Kimura models on a binary tree, our Grobner bases consist of certain explicitly constructed polynomials of degree at most four.

Toric ideals of phylogenetic invariants.

Algebraic statistics advocates polynomial algebra as a tool for addressing problems in statistics and its applications. This connection is based on the fact that most statistical models are defined either parametrically or implicitly via polynomial equations. The idea is summarized by the phrase "Statistical models are semialgebraic sets". My tutorial will consist of a detailed study of two examples where the algebra/statistics connection has proven especially useful: in the study of phylogenetic models and in the analysis of contingency tables.

Algebraic Statistics

Finite Gröbner bases in infinite dimensional polynomial rings and applications

We provide a characterization of the compressed lattice polytopes in terms of their facet defining inequalities and prove that every compressed lattice polytope is affinely isomorphic to a 0/1-polytope. As an application, we characterize those graphs whose cut polytopes are compressed and discuss consequences for studying linear programming relaxations in statistical disclosure limitation.

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Seth Sullivant

Papers

Lectures on Algebraic Statistics

Toric ideals of phylogenetic invariants.

Algebraic Statistics

Finite Gröbner bases in infinite dimensional polynomial rings and applications

Compressed polytopes and statistical disclosure limitation