Seymour Heisler

TL;DR: Results indicate that the inhibition of CRF, (-)-isoproterenol, and VIP-stimulated ACTH secretion by SRIF may be regulated by its inhibitory action on adenylate cyclase.

TL;DR: Corticotropin releasing factor (CRF) was tested for its ability to stimulate ACTH and β-endorphin secretion from clonal AtT-20 D16-16 mouse pituitary tumor cells and Dexamethasone markedly inhibited CRF-stimulated and basal ACTHand β- endorphin release.

TL;DR: Observations indicate that hormone-induced regulation of ACTH secretion converges at varying intracellular locations.

TL;DR: AtT-20 cells comprise a mouse anterior pituitary tumor cell line that synthesizes and secretes adrenocorticotropin hormone (ACTH) and the ability of beta-receptor agonists to stimulate intracellular cyclic adenosine 3′:5′-monophosphate (cAMP) formation and the release of ACTH immunoreactivity was characterized.

TL;DR: The enzymes involved in the turnover of carboxyl-methylated proteins are described and criteria to evaluate the role of these enzymes in exocytosis and chemotaxis are discussed.