Shadab Alam

TL;DR: The results showed that the copper(II) complex has significant antibacterial potential against Salmonella enteric comparable with ligand (DEEI) and standard drug ciprofloxacin and antioxidant assay demonstrated that scavenging activity of Cu( II) complex is higher as compared to ligand and ascorbic acid as standard.

TL;DR: 1,2,3-triazole and sulfonate analogues of natural bioactive precursors were designed and synthesized and 5e and 5u bearing carboxylic acid functionality emerged as potent antibacterial agents against S. pneumoniae and E. coli strains and significantly inhibited biofilm formation.

TL;DR: Two structural analogues of 3a (3b and 3c) have been synthesized to determine the role of quinoline and their anti-Candida activities have been evaluated, and preliminary results helped to determine 3a and 3b as lead inhibitors of C. albicans.

TL;DR: In vitro antibacterial screening against Gram-positive as well as Gram-negative bacterial strains identified compounds 8b and 8m with potent inhibitory potential against selective bacterial cells, which supports their biological potential.

TL;DR: Results of in vitro and in silico studies provide a rationale for selected compounds (2f, 4c and 4e) to be carried forward for further structural modifications and structure-activity relationship (SAR) studies against these bacterial infections.