Shailendra K. Saxena

TL;DR: Ricin, Shiga toxin, and Shiga-like toxin II (SLT-II, Vero toxin 2) exhibit an RNA N-glycosidase activity which specifically removes a single base near the 3' end of 28 S rRNA in isolated rat liver ribosomes and deproteinized28 S r RNA.

TL;DR: A unique role of the pyroglutamyl residue in the active site of amphibian RNases is indicated, and replacement of one to nine residues of onconase with the homologous residues of hRNase increased the enzymatic activity against most of the substrates tested with a simultaneous shift in the enzyme specificity from high preference for poly(U) to slight preference forpoly(C).

TL;DR: In this article , the authors analyzed the global perspective of Omicron, including transmission dynamic, effect on testing, and immunity, which shall promote the progress of the clinical application and basic research, and suggest that due to continuous variation in the spike glycoprotein sequences, the use of coronavirus specific attachment inhibitors may not be the current choice of therapy for emerging SARS-CoV-2 VOCs.

TL;DR: The data suggests that 2019-nCoV is newly spilled coronavirus into humans in China is closely related to SARS-CoV and may have a potential to become pandemic owing its antigenic discrepancy, and demonstration of novel Cytotoxic T lymphocyte epitopes may impart opportunities for the development of peptide based vaccine for the prevention of 2019- nCoV.

TL;DR: Protein synthesis was restored to angiogenin-injected oocytes by injecting the RNase inhibitor RNasin plus total Xenopus or calf liver tRNAs, thereby demonstrating that the tRNA degradation induced by angiogenicin was the sole cause of cytotoxicity.