S
Shannon Warburton
Researcher at Merck & Co.
Publications - 5
Citations - 226
Shannon Warburton is an academic researcher from Merck & Co.. The author has contributed to research in topics: Pichia pastoris & Glycan. The author has an hindex of 4, co-authored 5 publications receiving 210 citations.
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Journal ArticleDOI
Improvement of N-glycan site occupancy of therapeutic glycoproteins produced in Pichia pastoris
Byung-Kwon Choi,Shannon Warburton,Heping Lin,Rohan Patel,Istvan R. Boldogh,Michael Meehl,Marc d’Anjou,Liza A. Pon,Terrance A. Stadheim,Natarajan Sethuraman +9 more
TL;DR: The results suggest that the glycosylation status of recombinant proteins can be improved by heterologous STT3 expression, which will allow for the customization of therapeutic protein profiles.
Journal ArticleDOI
Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response
Byung-Kwon Choi,Jeffrey K. Actor,Sandra Rios,Marc d’Anjou,Terrance A. Stadheim,Shannon Warburton,Erin Giaccone,Michael Cukan,Huijuan Li,Angela Kull,Nathan Sharkey,Paul Gollnick,Maja Kocięba,Jolanta Artym,Michał Zimecki,Marian L. Kruzel,Stefan Wildt +16 more
TL;DR: It is established that glycoengineered P. pastoris strains are bioprocess compatible and the biological activity of the rhLF glycoforms produced was tested in vitro revealing the importance of N-acetylneuraminic (sialic) acid as a terminal sugar in propagation of proper immune responses.
Journal ArticleDOI
Maximizing recombinant human serum albumin production in a Mut(s) Pichia pastoris strain.
Muralidhar R. Mallem,Shannon Warburton,Fang Li,Ishaan Shandil,Adam Nylen,Sehoon Kim,Youwei Jiang,Michael Meehl,Marc d’Anjou,Terrance A. Stadheim,Byung-Kwon Choi +10 more
TL;DR: It is demonstrated that induction cell density is a critical factor for high level production of rHSA under controlled specific growth rate, and higher specific productivities at higher induction cell densities and at lower specific growth rates at induction.
Journal ArticleDOI
Regulation of alcohol oxidase 1 (AOX1) promoter and peroxisome biogenesis in different fermentation processes in Pichia pastoris
Sehoon Kim,Shannon Warburton,Istvan R. Boldogh,Cecilia Svensson,Liza A. Pon,Marc d’Anjou,Terrance A. Stadheim,Byung-Kwon Choi +7 more
TL;DR: It is suggested that the maximal production of a recombinant protein is highly dependent on methanol consumption rate that is affected by the availability of methanols and oxygen molecules.
Journal ArticleDOI
Erratum to: Improvement of N-glycan site occupancy of therapeutic glycoproteins produced in Pichia pastoris
Byung-Kwon Choi,Shannon Warburton,Heping Lin,Rohan Patel,Istvan R. Boldogh,Michael Meehl,Marc d’Anjou,Liza A. Pon,Terrance A. Stadheim,Natarajan Sethuraman +9 more
TL;DR: The author's name was given incorrectly, so the correct name is Michael Meehl for which the paper was correctly presented above.