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Sharianne G. Louie
Researcher at Pfizer
Publications - 8
Citations - 4204
Sharianne G. Louie is an academic researcher from Pfizer. The author has contributed to research in topics: Receptor tyrosine kinase & Myeloid leukemia. The author has an hindex of 8, co-authored 8 publications receiving 4107 citations. Previous affiliations of Sharianne G. Louie include Oregon Health & Science University.
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Journal ArticleDOI
SU6668 inhibits Flk-1/KDR and PDGFRβ in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice
A. Douglas Laird,James G. Christensen,Guangmin Li,Jeremy Carver,Kimberly A. Smith,Xiaohua Xin,Katherine G. Moss,Sharianne G. Louie,Dirk B. Mendel,Julie M. Cherrington +9 more
TL;DR: It is demonstrated that SU6668‐induced inhibition of angiogenic receptor tyrosine kinase activity in vivo is associated with rapid vessel killing in tumors, leading to broad and potent antitumor effects.
Journal ArticleDOI
CHIR-258: A Potent Inhibitor of FLT3 Kinase in Experimental Tumor Xenograft Models of Human Acute Myelogenous Leukemia
Daniel Menezes,Jing Peng,Evelyn N. Garrett,Sharianne G. Louie,Sang H. Lee,Marion Wiesmann,Yan Tang,Lee Shephard,Cheryl Goldbeck,Yoko Oei,Helen Ye,Sharon Lea Aukerman,Carla Heise +12 more
TL;DR: The data indicate that CHIR-258 may be an effective therapy in FLT3-associated AML and warrants clinical trials.
Journal ArticleDOI
Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia.
Anne Marie O'Farrell,Helene A. Yuen,Beverly Smolich,Alison L. Hannah,Sharianne G. Louie,Weiru Hong,Alison Stopeck,Lewis R. Silverman,Jeffrey E. Lancet,Judith E. Karp,Maher Albitar,Julie M. Cherrington,Francis J. Giles +12 more
TL;DR: Investigation of the effect of SU5416 on FLT3 expression and phosphorylation in blood and bone marrow was an additional focus of this trial, and translational and clinical analyses provide some insights into the mechanism and duration of action of SU 5416.