S
Shau Neen Liu-Cordero
Researcher at Massachusetts Institute of Technology
Publications - 3
Citations - 5925
Shau Neen Liu-Cordero is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Population & Sample size determination. The author has an hindex of 3, co-authored 3 publications receiving 5723 citations.
Papers
More filters
Journal ArticleDOI
The Structure of Haplotype Blocks in the Human Genome
Stacey Gabriel,Stephen F. Schaffner,Huy Nguyen,Jamie Moore,Jessica Roy,Brendan Blumenstiel,John M. Higgins,Matthew DeFelice,Amy L. Lochner,Maura Faggart,Shau Neen Liu-Cordero,Charles N. Rotimi,Adebowale Adeyemo,Richard S. Cooper,Ryk Ward,Eric S. Lander,Mark J. Daly,David Altshuler,David Altshuler +18 more
TL;DR: It is shown that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed.
Journal ArticleDOI
The Discovery of Single-Nucleotide Polymorphisms—and Inferences about Human Demographic History
TL;DR: An important conclusion of this work is that SNP data are useful only to the extent that their ascertainment can be modeled, and both the number of SNPs per SDL and their allele frequencies support a scenario of growth in effective size in the context of a subdivided population.
Journal ArticleDOI
Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion.
Kristin G. Ardlie,Shau Neen Liu-Cordero,Michael A. Eberle,Mark J. Daly,Jeffrey C. Barrett,Ellen Winchester,Eric S. Lander,Leonid Kruglyak +7 more
TL;DR: An estimate of effective human population size of 110,000 is calculated, an order of magnitude higher than most estimates based on nucleotide diversity and the most likely explanation is that gene conversion increases the apparent rate of recombination between nearby loci.