R
Ryk Ward
Researcher at University of Oxford
Publications - 70
Citations - 17356
Ryk Ward is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Haplotype. The author has an hindex of 44, co-authored 70 publications receiving 16768 citations. Previous affiliations of Ryk Ward include University College Hospital, Ibadan & Loyola University Chicago.
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Journal ArticleDOI
The Structure of Haplotype Blocks in the Human Genome
Stacey Gabriel,Stephen F. Schaffner,Huy Nguyen,Jamie Moore,Jessica Roy,Brendan Blumenstiel,John M. Higgins,Matthew DeFelice,Amy L. Lochner,Maura Faggart,Shau Neen Liu-Cordero,Charles N. Rotimi,Adebowale Adeyemo,Richard S. Cooper,Ryk Ward,Eric S. Lander,Mark J. Daly,David Altshuler,David Altshuler +18 more
TL;DR: It is shown that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed.
Journal ArticleDOI
Detecting recent positive selection in the human genome from haplotype structure
Pardis C. Sabeti,David Reich,John M. Higgins,Haninah Z P Levine,Daniel J. Richter,Stephen F. Schaffner,Stacey Gabriel,Jill Platko,Nick Patterson,Gavin J. McDonald,Hans Ackerman,Sarah J. Campbell,David Altshuler,David Altshuler,Richard H. Cooper,Dominic P. Kwiatkowski,Ryk Ward,Eric S. Lander +17 more
TL;DR: A framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations is introduced, and the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection.
Journal ArticleDOI
Linkage disequilibrium in the human genome
David Reich,Michele Cargill,Michele Cargill,Stacey Bolk,James S. Ireland,Pardis C. Sabeti,Daniel J. Richter,Thomas Lavery,Rose Kouyoumjian,Shelli F. Farhadian,Ryk Ward,Eric S. Lander +11 more
TL;DR: The results illuminate human history, suggesting that LD in northern Europeans is shaped by a marked demographic event about 27,000–53,000 years ago, implying that LD mapping is likely to be practical in this population.
Journal ArticleDOI
Informativeness of Genetic Markers for Inference of Ancestry
TL;DR: In a worldwide human microsatellite data set, a general measure, the informativeness for assignment (I(n), is introduced, applicable to any number of potential source populations, for determining the amount of information that multiallelic markers provide about individual ancestry.
Journal ArticleDOI
Race and Genomics
TL;DR: These two articles present contrasting views of the usefulness of the concept of race in biomedical research and clinical practice.