S
Shawn M. Sweeney
Researcher at American Association For Cancer Research
Publications - 12
Citations - 962
Shawn M. Sweeney is an academic researcher from American Association For Cancer Research. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 3, co-authored 6 publications receiving 577 citations.
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Journal ArticleDOI
AACR project genie: Powering precision medicine through an international consortium
Shawn M. Sweeney,Ethan Cerami,Alexander S. Baras,Trevor J. Pugh,Nikolaus Schultz,Thomas Stricker,James Lindsay,C. Del Vecchio Fitz,Priti Kumari,Christine M. Micheel,K. Shaw,Jianjiong Gao,Nicola Moore,Cyriac Kandoth,Brendan Reardon,Eva M Lepisto,Stuart Gardos,Kristen K. Dang,Justin Guinney,Larsson Omberg,Thomas Yu,Benjamin Gross,Zachary J. Heins,David M. Hyman,Barrett J. Rollins,Charles L. Sawyers,David B. Solit,Deborah Schrag,Victor E. Velculescu,Fabrice Andre,Philippe L. Bedard,Mia Levy,Gerrit A. Meijer +32 more
Journal ArticleDOI
American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond—Lessons Learned and Member Institutions’ Perspectives
Christine M. Micheel,Shawn M. Sweeney,Michele L. LeNoue-Newton,Fabrice Andre,Philippe L. Bedard,Justin Guinney,Gerrit A. Meijer,Barrett J. Rollins,Charles L. Sawyers,Nikolaus Schultz,Kenna R. Mills Shaw,Victor E. Velculescu,Mia A. Levy +12 more
TL;DR: The project’s history, operational structure, lessons learned, and institutional perspectives on participation in the data-sharing consortium are reviewed.
Journal ArticleDOI
Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry
Lillian M. Smyth,Qin Zhou,Bastien Nguyen,Celeste Yu,Eva M Lepisto,Monica Arnedos,Michael J Hasset,Michele LeNoue-Newton,Natalie M. Blauvelt,Semih Dogan,Christine M. Micheel,Chetna Wathoo,Hugo M. Horlings,Jan Hudecek,Benjamin Gross,Ritika Kundra,Shawn M. Sweeney,Jianjiong Gao,Nikolaus Schultz,Andrew Zarski,Stuart Gardos,Jocelyn A. Lee,Seth Sheffler-Collins,Ben Ho Park,Charles L. Sawyers,Fabrice Andre,Mia A. Levy,Funda Meric-Bernstam,Philippe L. Bedard,Alexia Iasonos,Deborah Schrag,David M. Hyman,David M. Hyman +32 more
TL;DR: The feasibility of using a novel and publicly accessible clincogenomic registry to define outcomes in a rare genomically defined cancer subtype is demonstrated, an approach with broad applicability to precision oncology.
Journal ArticleDOI
Implications of Selection Bias Due to Delayed Study Entry in Clinical Genomic Studies.
Samantha Brown,Jessica A. Lavery,Ronglai Shen,Axel Martin,Kenneth L. Kehl,Shawn M. Sweeney,Eva M Lepisto,Hira Rizvi,Caroline G. McCarthy,Nikolaus Schultz,Jeremy L. Warner,Ben Ho Park,Philippe L. Bedard,Gregory J. Riely,Deborah Schrag,Deborah Schrag,Katherine S. Panageas +16 more
TL;DR: In this article, the effects of ignoring left truncation when estimating overall survival are illustrated using data from the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange Biopharma Collaborative (GENIE BPC), and a straightforward risk set adjustment approach is described.
Journal ArticleDOI
Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non-Small Cell Lung or Colorectal Cancer.
Kenneth L. Kehl,Gregory J. Riely,Eva M Lepisto,Jessica A. Lavery,Jeremy L. Warner,Michele LeNoue-Newton,Shawn M. Sweeney,Julia E. Rudolph,Samantha Brown,Celeste Yu,Philippe L. Bedard,Philippe L. Bedard,Deborah Schrag,Katherine S. Panageas +13 more
TL;DR: In this article, a retrospective cohort study was conducted of patients with non-small cell lung cancer (NSCLC) or colorectal cancer (CRC) whose tumors were genotyped at 4 academic centers from January 1, 2014, to December 31, 2017, and who initiated systemic therapy for advanced disease.