S
Shehab S. Ahmed
Researcher at Bangladesh University of Engineering and Technology
Publications - 7
Citations - 82
Shehab S. Ahmed is an academic researcher from Bangladesh University of Engineering and Technology. The author has contributed to research in topics: Population & Computer science. The author has an hindex of 3, co-authored 5 publications receiving 34 citations.
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Journal ArticleDOI
Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.
Sumaiya Iqbal,Eduardo Pérez-Palma,Jakob Berg Jespersen,Patrick May,David Hoksza,David Hoksza,Henrike O. Heyne,Henrike O. Heyne,Henrike O. Heyne,Shehab S. Ahmed,Zaara T. Rifat,M. Sohel Rahman,Kasper Lage,Kasper Lage,Aarno Palotie,Aarno Palotie,Jeffrey R. Cottrell,Florence F. Wagner,Mark J. Daly,Arthur J. Campbell,Dennis Lal +20 more
TL;DR: A wide-scale characterization of missense variants from 1,330 disease-associated genes using >14,000 protein structures is performed, identifying 3D features associated with pathogenic and benign variants that unveiled the mutations’ effect at the molecular level.
Journal ArticleDOI
MISCAST: MIssense variant to protein StruCture Analysis web SuiTe.
Sumaiya Iqbal,Sumaiya Iqbal,David Hoksza,David Hoksza,Eduardo Pérez-Palma,Patrick May,Jakob Berg Jespersen,Shehab S. Ahmed,Zaara T. Rifat,Henrike O. Heyne,Henrike O. Heyne,Henrike O. Heyne,M. Sohel Rahman,Jeffrey R. Cottrell,Florence F. Wagner,Mark J. Daly,Mark J. Daly,Mark J. Daly,Arthur J. Campbell,Dennis Lal +19 more
TL;DR: MISCAST is an interactive and user-friendly web server to visualize and analyzemissense variants in protein sequence and structure space and made the annotated data and protein structures readily downloadable from MISCAST to foster advanced offline analysis of missense variants by a wide biological community.
Posted ContentDOI
Insights into protein structural, physicochemical, and functional consequences of missense variants in 1,330 disease-associated human genes 693259
Sumaiya Iqbal,Sumaiya Iqbal,Jakob Berg Jespersen,Jakob Berg Jespersen,Eduardo Pérez-Palma,Patrick May,David Hoksza,Henrike O. Heyne,Shehab S. Ahmed,Zaara T. Rifat,M. Sohel Rahman,Kasper Lage,Kasper Lage,Aarno Palotie,Aarno Palotie,Jeffrey R. Cottrell,Florence F. Wagner,Mark J. Daly,Arthur C. Campbell,Dennis Lal +19 more
TL;DR: The aggregation and analysis of large-scale genomic variation and structural biology data for 1,330 disease-associated genes is described and a quantitative spectrum is devised, identifying variants with higher pathogenic variant-associated features.
Journal ArticleDOI
Characterization of intrinsically disordered regions in proteins informed by human genetic diversity
Shehab S. Ahmed,Zaara T. Rifat,Ruchi Lohia,Arthur J. Campbell,A. Keith Dunker,Mohammad Sohel Rahman,Sumaiya Iqbal +6 more
TL;DR: This study presents a novel approach to assign functional importance to IDRs by leveraging the wealth of available genetic data, which will aid in a deeper understating of the role of IDRs in biological processes and disease mechanisms.
Posted ContentDOI
Burden analysis of missense variants in 1,330 disease-associated genes on 3D provides insights into the mutation effects
Sumaiya Iqbal,Jakob Berg Jespersen,Eduardo Pérez-Palma,Patrick May,David Hoksza,Henrike O. Heyne,Shehab S. Ahmed,Zaara T. Rifat,Md. Saidur Rahman,Kasper Lage,Aarno Palotie,Cottrell,Florence F. Wagner,Mark J. Daly,Arthur J. Campbell,Dennis Lal +15 more
TL;DR: The burden of amino acids affected in pathogenic variants is evaluated compared to the variants from the general population in 1,330 disease-associated genes on forty protein features using over 14,000 experimentally-solved 3D structures to demonstrate the pathogenicity of variants in terms of the perturbed molecular mechanisms.