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Sheila E. Francis
Researcher at University of Sheffield
Publications - 183
Citations - 7561
Sheila E. Francis is an academic researcher from University of Sheffield. The author has contributed to research in topics: Inflammation & Endothelial stem cell. The author has an hindex of 48, co-authored 178 publications receiving 6708 citations. Previous affiliations of Sheila E. Francis include Royal Hallamshire Hospital & Northern General Hospital.
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Journal ArticleDOI
Microbubble-enhanced ultrasound for vascular gene delivery
Allan Lawrie,Axel F. Brisken,Sheila E. Francis,David C. Cumberland,David C. Crossman,Chris Newman +5 more
TL;DR: It is reported here that performing USE in the presence of microbubble echocontrast agents enhances acoustic cavitation and is associated with approximately 300-fold increments in transgene expression after naked DNA transfections, which indicates an important role foroustic cavitation in the effects of USE.
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Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies
Sheila E. Francis,Keow Lin Goh,Kairbaan Hodivala-Dilke,Bernhard L. Bader,M. Stark,Duncan Davidson,Richard O. Hynes +6 more
TL;DR: It is shown that the alpha5 integrin subunit and fibronectin have critical roles in blood vessel development in mouse embryos and in embryoid bodies differentiated from embryonic stem cells, and successful early vasculogenesis and angiogenesis require alpha5-FN interactions.
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Interleukin-1 beta in coronary arteries of patients with ischemic heart disease.
TL;DR: It is concluded that IL-1 beta is produced by endothelial cells and macrophages in coronary arteries from ischemic hearts and to a lesser extent from nonischemic cardiomyopathic hearts.
Journal ArticleDOI
Interleukin-1 Receptor Antagonist Gene Polymorphism and Coronary Artery Disease
Sheila E. Francis,Nicola J. Camp,Rachael Dewberry,Julian Gunn,Petros Syrris,Nicholas D. Carter,Stephen Jeffery,Juan Carlos Kaski,David C. Cumberland,Gordon W. Duff,David C. Crossman +10 more
TL;DR: IL-1RN*2 was significantly associated with SVD, and a difference in genetic association between SVD and MVD was also apparent.