S
Shendra R. Miller
Researcher at Drexel University
Publications - 11
Citations - 519
Shendra R. Miller is an academic researcher from Drexel University. The author has contributed to research in topics: Vaginal microbicide & Microbicide. The author has an hindex of 9, co-authored 11 publications receiving 502 citations. Previous affiliations of Shendra R. Miller include Pennsylvania State University.
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Journal ArticleDOI
Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate
TL;DR: These studies suggest that C31G and SDS may be attractive candidates for human trials as topical microbicides effective against HIV-1 transmission since both function at concentrations that provide effective viral inactivation with low levels of cytotoxicity.
Journal ArticleDOI
Polybiguanides, particularly polyethylene hexamethylene biguanide, have activity against human immunodeficiency virus type 1.
Fred C. Krebs,Shendra R. Miller,Mary L Ferguson,Mohamed E. Labib,Robert F. Rando,Brian Wigdahl +5 more
TL;DR: In this article, modified versions of polyhexamethylene biguanide (PHMB) incorporating length changes in the hydrocarbon linker units were synthesized and evaluated for in vitro cytotoxicity and inhibition of HIV-1 infectivity.
Journal ArticleDOI
Sodium dodecyl sulfate and C31G as microbicidal alternatives to nonoxynol 9: comparative sensitivity of primary human vaginal keratinocytes.
Fred C. Krebs,Shendra R. Miller,Bradley J. Catalone,Patricia A. Welsh,Daniel Malamud,Mary K. Howett,Brian Wigdahl +6 more
TL;DR: Results reveal important variations in time- and concentration-dependent sensitivity to N-9, C31G, or SDS within populations of primary human vaginal keratinocytes cultured in vitro.
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In Vitro Preclinical Testing of Nonoxynol-9 as Potential Anti-Human Immunodeficiency Virus Microbicide: a Retrospective Analysis of Results from Five Laboratories
Brigitte E. Beer,Gustavo F. Doncel,Fred C. Krebs,Robin J. Shattock,Patricia S. Fletcher,Robert W. Buckheit,Karen M. Watson,Charlene S. Dezzutti,James E. Cummins,Ena Bromley,Nicola Richardson-Harman,Luke A. Pallansch,Carol Lackman-Smith,Clay Osterling,Marie K. Mankowski,Shendra R. Miller,Bradley J. Catalone,Patricia A. Welsh,Mary K. Howett,Brian Wigdahl,Jim A. Turpin,Patricia Reichelderfer +21 more
TL;DR: This is the first analysis to compare preclinical N-9 toxicity levels that were obtained by different laboratories using various protocols and can be used to develop standardized microbicide testing protocols that will help advance potential microbicides to clinical trials.
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Comparative In Vitro Sensitivities of Human Immune Cell Lines, Vaginal and Cervical Epithelial Cell Lines, and Primary Cells to Candidate Microbicides Nonoxynol 9, C31G, and Sodium Dodecyl Sulfate
Fred C. Krebs,Shendra R. Miller,Bradley J. Catalone,Raina N. Fichorova,Deborah J. Anderson,Daniel Malamud,Mary K. Howett,Brian Wigdahl +7 more
TL;DR: These studies provide a foundation for in vitro experiments in which cell lines of human immune and epithelial origin can be used as suitable surrogates for primary cells to further investigate the effects of microbicides on cell metabolism, membrane composition, and integrity and theeffects of cell type, proliferation, and differentiation on microbicide sensitivity.