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Raina N. Fichorova
Researcher at Brigham and Women's Hospital
Publications - 214
Citations - 9403
Raina N. Fichorova is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Gestational age & Pregnancy. The author has an hindex of 52, co-authored 196 publications receiving 7850 citations. Previous affiliations of Raina N. Fichorova include Boston Children's Hospital & Sofia Medical University.
Papers
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Journal ArticleDOI
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract
Melis N. Anahtar,Melis N. Anahtar,Elizabeth H. Byrne,Kathleen E. Doherty,Brittany A. Bowman,Hidemi S. Yamamoto,Magali Soumillon,Nikita Padavattan,Nasreen Ismail,Amber Moodley,Mary E. Sabatini,Musie Ghebremichael,Chad Nusbaum,Curtis Huttenhower,Herbert W. Virgin,Thumbi Ndung'u,Thumbi Ndung'u,Krista L. Dong,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Raina N. Fichorova,Douglas S. Kwon,Douglas S. Kwon +23 more
TL;DR: This study proposes a mechanism by which cervicovaginal microbiota impact genital inflammation and thereby might affect a woman's reproductive health, including her risk of acquiring HIV.
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The Human Microbiome during Bacterial Vaginosis
TL;DR: A careful analysis of the available data suggests that what the authors term BV is a set of common clinical signs and symptoms that can be provoked by a plethora of bacterial species with proinflammatory characteristics, coupled to an immune response driven by variability in host immune function.
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The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission.
TL;DR: In vitro and in vivo model systems are identified for monitoring undesirable proinflammatory effects of microbicides and other vaginal products to link N-9-induced vaginal inflammation to increased risk of HIV-1 infection.
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Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins.
TL;DR: The morphological and immunocytochemical characteristics of the immortalized lines closely resembled those of their respective tissues of origin and primary cultures, and all differed significantly from the HeLa cervical adenocarcinoma cell line.
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Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling.
TL;DR: It is demonstrated that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling, and soluble CD14 can act as a coreceptor for non-TLR4 ligands.