Journal ArticleDOI
Demyelination increases radial diffusivity in corpus callosum of mouse brain.
Sheng-Kwei Song,Jun E. Yoshino,Jun E. Yoshino,Tuan Q. Le,Shiow Jiuan Lin,Shu-Wei Sun,Anne H. Cross,Regina C. Armstrong,Regina C. Armstrong +8 more
TLDR
In this article, the authors used diffusion tensor imaging (DTI) derived parameters to assess the extent of axonal damage, demyelination and axonal degeneration.About:
This article is published in NeuroImage.The article was published on 2005-05-15. It has received 1570 citations till now. The article focuses on the topics: Remyelination & White matter.read more
Citations
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Journal ArticleDOI
Diffusion Tensor Imaging of the Brain
TL;DR: Diffusion tensor imaging (DTI) is a promising method for characterizing microstructural changes or differences with neuropathology and treatment and the biological mechanisms, acquisition, and analysis of DTI measurements are addressed.
Journal ArticleDOI
Microstructural maturation of the human brain from childhood to adulthood.
TL;DR: Differences observed in developmental timing suggest a pattern of maturation in which areas with fronto-temporal connections develop more slowly than other regions, which is consistent with previous postmortem and imaging studies.
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Motor Control and Aging: Links to Age-Related Brain Structural, Functional, and Biochemical Effects
Rachael D. Seidler,Jessica A. Bernard,Taritonye B. Burutolu,Brett W. Fling,Mark T. Gordon,Joseph T. Gwin,Youngbin Kwak,David B. Lipps +7 more
TL;DR: In general, older adults exhibit involvement of more widespread brain regions for motor control than young adults, particularly the prefrontal cortex and basal ganglia networks, resulting in an imbalance of "supply and demand".
Journal ArticleDOI
Longitudinal Development of Human Brain Wiring Continues from Childhood into Adulthood
TL;DR: Volume increased significantly with age for most tracts, and longitudinal measures also demonstrated postadolescent volume increases in several association tracts, which likely reflect microstructural maturation of brain white matter tracts rather than just gross anatomy.
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Diffusion tensor imaging of white matter tract evolution over the lifespan
Catherine Lebel,Michael S. Gee,Richard Camicioli,Marguerite Wieler,W.R. Wayne Martin,Christian Beaulieu +5 more
TL;DR: Clear age-related microstructural changes throughout the brain white matter are demonstrated, and normative data is provided that will be useful for studying white matter development in a variety of diseases and abnormal conditions.
References
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
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Toward a quantitative assessment of diffusion anisotropy
Carlo Pierpaoli,Peter J. Basser +1 more
TL;DR: New indices calculated from the entire diffusion tensor are rotationally invariant (RI) and show that anisotropy is highly variable in different white matter regions depending on the degree of coherence of fiber tract directions.
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Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water
Sheng-Kwei Song,Shu-Wei Sun,Shu-Wei Sun,Michael J. Ramsbottom,Chen Chang,John H. Russell,Anne H. Cross +6 more
TL;DR: The use of magnetic resonance diffusion tensor imaging to quantify the effect of dysmyelination on water directional diffusivities in brains of shiverer mice in vivo suggests that changes in lambda(perpendicular) and lambda(parallel) may potentially be used to differentiate myelin loss versus axonal injury.
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Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia.
TL;DR: The hypothesis that lambdaparallel and lambdaperpendicular hold promise as specific markers of axonal and myelin injury, respectively, and, further, that the coexistence of axon andMyelin degeneration does not confound this utility, are supported.
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Axonal damage in acute multiple sclerosis lesions.
TL;DR: The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.