S
Shengbin Li
Publications - 2
Citations - 91
Shengbin Li is an academic researcher. The author has contributed to research in topics: Aryl & Alkoxy group. The author has an hindex of 2, co-authored 2 publications receiving 89 citations.
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Patent
Benzylbenzene derivatives and methods of use
Yuanwei Chen,Cheng Huawei,Shengbin Li,Wu Yuelin,Yan Feng,Binhua Lv,Baihua Xu,Brian Seed,Michael J. Hadd,Yanli Song,Jiyan Du,Congna Wang,Jacques Y. Roberge +12 more
TL;DR: In this paper, compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT are provided. And the authors also provide pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by sGLT inhibition.
Journal ArticleDOI
C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
Baihua Xu,Yan Feng,Cheng Huawei,Yanli Song,Binhua Lv,Wu Yuelin,Congna Wang,Shengbin Li,Min Xu,Jiyan Du,Kun Peng,Jiajia Dong,Wenbin Zhang,Ting Zhang,Liangcheng Zhu,Haifeng Ding,Zelin Sheng,Ajith Welihinda,Jacques Y. Roberge,Brian Seed,Yuanwei Chen +20 more
TL;DR: Introduction of alkyl or alkoxy substituents at the 4'-position of the distal aryl ring was found to improve SGLT2 potency, whereas introduction of a hydrophilic group at this position was deleterious.