Z
Zelin Sheng
Publications - 12
Citations - 311
Zelin Sheng is an academic researcher. The author has contributed to research in topics: In vivo & Aryl. The author has an hindex of 9, co-authored 12 publications receiving 289 citations.
Papers
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Journal ArticleDOI
EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA1c levels in db/db mice and prolongs the survival of stroke-prone rats
Wenbin Zhang,Ajith Welihinda,Jordan Mechanic,Haifeng Ding,Liangcheng Zhu,Yuan Lu,Zhongping Deng,Zelin Sheng,Binhua Lv,Yuanwei Chen,Jacques Y. Roberge,Brian Seed,Yong-Xiang Wang +12 more
TL;DR: EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients and could help to promote normalization of blood glucose without hypoglycemia in the setting of type 1 diabetes.
Journal ArticleDOI
Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.
Ge Xu,Binhua Lv,Jacques Y. Roberge,Baihua Xu,Jiyan Du,Jiajia Dong,Yuanwei Chen,Kun Peng,Lili Zhang,Xinxing Tang,Yan Feng,Min Xu,Wei Fu,Wenbin Zhang,Liangcheng Zhu,Zhongping Deng,Zelin Sheng,Ajith Welihinda,Xun Sun +18 more
TL;DR: S GLT2 inhibitors deuterated at sites susceptible to oxidative metabolism were found to have a slightly longer tmax and half-life, dose-dependent increase in urinary glucose excretion in rats, and slightly superior effects on UGE in dogs while retaining similar in vitro inhibitory activities against hSGLT2.
Journal ArticleDOI
Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Binhua Lv,Baihua Xu,Yan Feng,Kun Peng,Ge Xu,Jiyan Du,Lili Zhang,Wenbin Zhang,Ting Zhang,Liangcheng Zhu,Haifeng Ding,Zelin Sheng,Ajith Welihinda,Brian Seed,Yuanwei Chen +14 more
TL;DR: The core spiro[isobenzofuran-1,2'-pyran] structure proved to be an effective scaffold for diversification and a number of compounds with single digit nanomolar potency and high selectivity have been synthesized.
Patent
Benzylic glycoside derivatives and methods of use
Yuanwei Chen,Yan Feng,Baihua Xu,Binhua Lv,Brian Seed,Michael J. Hadd,Cheng Huawei,Zelin Sheng,Min Xu,Congna Wang,Jiyan Du,Lili Zhang,Ge Xu,Wu Yuelin +13 more
TL;DR: In this paper, compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT are provided. And the authors also provide pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by sGLT inhibition.
Journal ArticleDOI
C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
Baihua Xu,Yan Feng,Cheng Huawei,Yanli Song,Binhua Lv,Wu Yuelin,Congna Wang,Shengbin Li,Min Xu,Jiyan Du,Kun Peng,Jiajia Dong,Wenbin Zhang,Ting Zhang,Liangcheng Zhu,Haifeng Ding,Zelin Sheng,Ajith Welihinda,Jacques Y. Roberge,Brian Seed,Yuanwei Chen +20 more
TL;DR: Introduction of alkyl or alkoxy substituents at the 4'-position of the distal aryl ring was found to improve SGLT2 potency, whereas introduction of a hydrophilic group at this position was deleterious.