Shengsheng Cai

TL;DR: This review summarized and discussed the recent strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy, including optimizing the intrinsic physicochemical properties and external modification.

TL;DR: In this paper, a dual drug-loaded core-shell nanoparticles (DLTPT) consisting of CD44-targeting hyaluronic acid shells decorated with doxorubicin (HA-DOX) and mitochondria-targeted triphenylphosphonium derivative nanoparticle cores loaded with lonidamine (LND) dimers (LTPT).

TL;DR: In this paper, a fluorocarbon-driven IR780 assembly was constructed to unlock the photochemical conversion pathway for suppressing breast tumor, and the assembly suppressed photothermal represented nonradiative relaxation and considerably elevated collisional energy transfer for reactive oxygen species (ROS)-represented chemical energy.

TL;DR: An all in one nano-system with active-targeting, enzyme-triggered deshielding and positive-charge characteristics was fabricated for chemo/photo-combination therapy to allow efficient tumor targeting, cellular internalization and lysosomal escape.

TL;DR: In vitro and in vivo studies demonstrated that the released AFT and excessive ROS at the local site can synergistically induce cell apoptosis to enhance the therapeutic efficacy without side effects.