Shenping Liu

TL;DR: The structure of the catalytic complex of GK has been determined, and multiple conformations have been directly observed in solution, and a modified mnemonic model is proposed to explain cooperativity in GK.

TL;DR: The structure-based design of a highly selective inhibitor of the CREB binding protein (CBP) bromodomain is described and its use in cell-based transcriptional profiling experiments is described, suggesting a potential therapeutic opportunity for CBP inhibitors in the treatment of neurological disorders.

TL;DR: A high affinity IL-17A peptide antagonist (HAP) of 15 residues was identified through phage-display screening followed by saturation mutagenesis optimization and amino acid substitutions and suggests opportunities for developing peptide antagonists against this challenging target.

TL;DR: Investigation of a series of linear peptide ligands to IL-17A and characterization of their binding site has enabled the design of novel macrocyclic ligands that are themselves potent IL- 17A antagonists.

TL;DR: The authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMp-2 luminal domain dimer and discuss its lipid trafficking mechanism.