S
Sherin Ali Nawaito
Researcher at Montreal Heart Institute
Publications - 8
Citations - 43
Sherin Ali Nawaito is an academic researcher from Montreal Heart Institute. The author has contributed to research in topics: Pressure overload & Afterload. The author has an hindex of 3, co-authored 6 publications receiving 29 citations. Previous affiliations of Sherin Ali Nawaito include Université de Montréal.
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Journal ArticleDOI
MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart
Sherin Ali Nawaito,Sherin Ali Nawaito,Dharmendra Dingar,Dharmendra Dingar,Pramod Sahadevan,Pramod Sahadevan,Bahira Hussein,Fatiha Sahmi,Yanfen Shi,Marc-Antoine Gillis,Matthias Gaestel,Jean-Claude Tardif,Jean-Claude Tardif,Bruce G. Allen +13 more
TL;DR: Reduced MK5 expression in cardiac fibroblasts was associated with the attenuation of both hypertrophy and development of a restrictive filling pattern during myocardial remodeling in response to chronic pressure overload.
Journal ArticleDOI
MK5 haplodeficiency decreases collagen deposition and scar size during post-myocardial infarction wound repair.
Sherin Ali Nawaito,Pramod Sahadevan,Marie-Élaine Clavet-Lanthier,Philippe Pouliot,Fatiha Sahmi,Yanfen Shi,Marc-Antoine Gillis,Frédéric Lesage,Matthias Gaestel,Martin G. Sirois,Martin G. Sirois,Angelo Calderone,Angelo Calderone,Jean-Claude Tardif,Bruce G. Allen,Bruce G. Allen +15 more
TL;DR: Reduced MK5 expression alters fibroblast function and scar morphology but not mortality post-MI, and reduces infarct size, scar area, and scar collagen content post-myocardial infarction.
Journal ArticleDOI
Transcript levels for extracellular matrix proteins are altered in MK5-deficient cardiac ventricular fibroblasts.
Sherin Ali Nawaito,Pramod Sahadevan,Fatiha Sahmi,Matthias Gaestel,Angelo Calderone,Angelo Calderone,Bruce G. Allen +6 more
TL;DR: Results indicate that MK5 may be involved in fibroblast-mediated regulation of extracellular matrix homeostasis in cardiac fibroblasts and myocytes.
Journal ArticleDOI
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy
Gerald Coulis,Avinash D. Londhe,Reddy Sudheer Sagabala,Yanfen Shi,David P. Labbé,Alexandre Bergeron,Pramod Sahadevan,Sherin Ali Nawaito,Fatiha Sahmi,M. Josse,Valérie Vinette,Marie-Claude Guertin,Gerard Karsenty,Michel L. Tremblay,Jean-Claude Tardif,Bruce G. Allen,Benoit Boivin +16 more
TL;DR: The data illustrate that PTP1B activity is cardioprotective and that redox signaling is linked to thyroid hormone responsiveness and microRNA-mediated gene silencing in pathological hypertrophy.
Journal ArticleDOI
MK2-Deficient Mice Are Bradycardic and Display Delayed Hypertrophic Remodeling in Response to a Chronic Increase in Afterload.
Matthieu Ruiz,Maya Khairallah,Dharmendra Dingar,Dharmendra Dingar,George Vaniotis,George Vaniotis,Ramzi J. Khairallah,Benjamin Lauzier,Simon Thibault,Joëlle Trépanier,Joëlle Trépanier,Yanfen Shi,Annie Douillette,Bahira Hussein,Sherin Ali Nawaito,Pramod Sahadevan,Pramod Sahadevan,Albert Nguyen,Albert Nguyen,Fatiha Sahmi,Marc-Antoine Gillis,Martin G. Sirois,Martin G. Sirois,Matthias Gaestel,William C. Stanley,Céline Fiset,Céline Fiset,Jean-Claude Tardif,Jean-Claude Tardif,Bruce G. Allen +29 more
TL;DR: In this paper, the authors examined the cardiac phenotype of pan MK2−null (MK2−−α/β) and showed that MK2 −−α is a protein serine/threonine kinase activated by p38α/γ/β.