S
Shernaz X. Bamji
Researcher at University of British Columbia
Publications - 47
Citations - 4249
Shernaz X. Bamji is an academic researcher from University of British Columbia. The author has contributed to research in topics: Synapse & Palmitoylation. The author has an hindex of 30, co-authored 42 publications receiving 3817 citations. Previous affiliations of Shernaz X. Bamji include Montreal Neurological Institute and Hospital & University of California, San Francisco.
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Journal ArticleDOI
The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death
Shernaz X. Bamji,Marta Majdan,Christine D. Pozniak,Daniel J. Belliveau,Raquel Aloyz,Judi Kohn,Carrie G. Causing,Freda D. Miller +7 more
TL;DR: It is shown that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death, which is intrinsic to sympathetic neurons.
Journal ArticleDOI
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
Arya E. Mehran,Nicole M. Templeman,G. Stefano Brigidi,Gareth E. Lim,Kwan-Yi Chu,Xiaoke Hu,José Diego Botezelli,Ali Asadi,Bradford G. Hoffman,Timothy J. Kieffer,Shernaz X. Bamji,Susanne M. Clee,James D. Johnson +12 more
TL;DR: Genetic evidence that pathological circulating hyperinsulinemia drives diet-induced obesity and its complications is provided and white adipose tissue is reprogrammed to express uncoupling protein 1 and increase energy expenditure.
Journal ArticleDOI
P53 is essential for developmental neuron death as regulated by the trka and p75 neurotrophin receptors
Raquel Aloyz,Shernaz X. Bamji,Christine D. Pozniak,Jean G. Toma,Jasvinder K. Atwal,David L. Kaplan,Freda D. Miller +6 more
TL;DR: It is demonstrated that the p53 tumor suppressor protein is an essential component of both of these apoptotic signaling cascades that converge on the MEKK-JNK pathway to regulate the developmental death of sympathetic neurons.
Journal ArticleDOI
Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly
Shernaz X. Bamji,Kazuhiro Shimazu,Nikole E. Kimes,Joerg Huelsken,Walter Birchmeier,Bai Lu,Louis F. Reichardt +6 more
TL;DR: A role for beta-catenin is shown in localizing the reserved pool of vesicles at presynaptic sites by modulating vesicle localization via its PDZ binding domain to recruit PDZ proteins such as Veli to cadherin at synapses.
Journal ArticleDOI
Synaptic Innervation Density Is Regulated by Neuron-Derived BDNF
Carrie G. Causing,Andrew T. Gloster,Raquel Aloyz,Shernaz X. Bamji,Eddie Chang,Jim Fawcett,George A. Kuchel,Freda D. Miller +7 more
TL;DR: Results indicate that variations in neuronal neurotrophin synthesis directly regulate neuronal circuitry by selectively modulating synaptic innervation density.