L
Louis F. Reichardt
Researcher at University of California, San Francisco
Publications - 243
Citations - 45322
Louis F. Reichardt is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Neurotrophin & Integrin. The author has an hindex of 108, co-authored 243 publications receiving 43210 citations. Previous affiliations of Louis F. Reichardt include University of Hamburg & University of California.
Papers
More filters
Journal ArticleDOI
Neurotrophins: roles in neuronal development and function.
Eric J. Huang,Louis F. Reichardt +1 more
TL;DR: Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems, and control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival.
Journal ArticleDOI
Trk receptors: roles in neuronal signal transduction.
Eric J. Huang,Louis F. Reichardt +1 more
TL;DR: The most fascinating aspect of Trk receptor-mediated signaling is its interplay with signaling promoted by the pan-neurotrophin receptor p75NTR, which activates a distinct set of signaling pathways within cells that are in some instances synergistic and in other instances antagonistic to those activated by Trk receptors.
Journal ArticleDOI
Neurotrophin-regulated signalling pathways
TL;DR: Three rare human genetic disorders, which result in deleterious effects on sensory perception, cognition and a variety of behaviours, have been shown to be attributable to mutations in brain-derived neurotrophic factor and two of the Trk receptors.
Journal ArticleDOI
Renal and neuronal abnormalities in mice lacking GDNF.
Mark W. Moore,Robert D. Klein,Isabel Fariñas,Hansjorg Sauer,Mark Armanini,Heidi S. Phillips,Louis F. Reichardt,Anne M. Ryan,Karen Carver-Moore,Arnon Rosenthal +9 more
TL;DR: It is shown that at postnatal day 0 (P0), GDNF-deficient mice have deficits in dorsal root ganglion, sympathetic and nodose neurons, but not in hindbrain noradrenergic or midbrain dopaminergic neurons, and GDNF is important for the development and/or survival of enteric, sympathetic, and sensory neurons and the renal system, but is not essential for catecholaminergic neuron in the central nervous system (CNS).
Journal ArticleDOI
Trk receptors: mediators of neurotrophin action
TL;DR: Three-dimensional structures of the Trk receptors, in one instance in association with a neurotrophin, have revealed the structural bases underlying specificity in neurotrophIn signaling, where key intermediates are localized to different membrane compartments.