Shigeru Hokari

TL;DR: In this paper, the effects of four 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (pravastatin, simvastatin and fluvastatatin) on the production and expression of inflammatory cytokines and on enzyme expression involving prostaglandin and superoxide production in cultured human umbilical vein endothelial cells (HUVEC) were examined.

TL;DR: Three‐dimensional collagen gel culture experiments of the AV endocardium show that myocardially derived inductive signals upregulate the expression of AV endothelial TGFβ3 at the onset of EMT, and TGF β3 needs to be expressed by these endothelial cells to trigger the initial phenotypic changes of E MT.

TL;DR: The results suggest that PPARalpha and PPARgamma gene and protein expression in endothelial cells may play a physiologic role as radical scavengers, although the details of these mechanisms remain to be established.

TL;DR: The results strongly suggest that the APs reduced the toxicity of LPS, as a host defense factor against LPS.

TL;DR: Taking all of the above findings together, ox-HDL activates NF-κB via binding to LOX-1 on the cell surface, followed by enhancement of intracellular ROS production in endothelial cells.