T
Toshiyuki Mastunaga
Researcher at Saitama Medical University
Publications - 2
Citations - 438
Toshiyuki Mastunaga is an academic researcher from Saitama Medical University. The author has contributed to research in topics: 7-Dehydrocholesterol reductase & HMG-CoA reductase. The author has an hindex of 2, co-authored 2 publications receiving 424 citations.
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Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect
Ikuo Inoue,Sei-ichi Goto,Kasumi Mizotani,Takuya Awata,Toshiyuki Mastunaga,Shin-ichiro Kawai,Takanori Nakajima,Shigeru Hokari,Tugikazu Komoda,Shigehiro Katayama +9 more
TL;DR: In this paper, the effects of four 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (pravastatin, simvastatin and fluvastatatin) on the production and expression of inflammatory cytokines and on enzyme expression involving prostaglandin and superoxide production in cultured human umbilical vein endothelial cells (HUVEC) were examined.
Journal ArticleDOI
Fibrate and Statin Synergistically Increase the Transcriptional Activities of PPARα/RXRα and Decrease the Transactivation of NFκB
Ikuo Inoue,Fumiaki Itoh,Shigemi Aoyagi,Shigeki Tazawa,Hiroshi Kusama,Masuo Akahane,Toshiyuki Mastunaga,Kenji Hayashi,Takuya Awata,Tugikazu Komoda,Sigehiro Katayama +10 more
TL;DR: It is found that bezafibrate was a ligand for PPARα, δ, and γ in the CARLA and that befibrate induced transcriptional activation of PPAR α/RXRα, PPARδ/R XR α, and PPARγ/RxRα.