T
Takuya Awata
Researcher at International University of Health and Welfare
Publications - 141
Citations - 8277
Takuya Awata is an academic researcher from International University of Health and Welfare. The author has contributed to research in topics: Diabetes mellitus & Type 1 diabetes. The author has an hindex of 45, co-authored 138 publications receiving 7800 citations. Previous affiliations of Takuya Awata include University of Tokyo & University of Massachusetts Amherst.
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Journal ArticleDOI
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Diether Lambrechts,Erik Storkebaum,Masafumi Morimoto,Jurgen Del-Favero,Frederik Desmet,Stefan L. Marklund,Sabine Wyns,Vincent Thijs,Jörgen Andersson,Ingrid van Marion,Ammar Al-Chalabi,Stéphanie Bornes,Rhiannon Musson,Valerie K. Hansen,Lars Beckman,Rolf Adolfsson,Hardev Pall,Hervé Prats,Severine Vermeire,Paul Rutgeerts,Shigehiro Katayama,Takuya Awata,Nigel Leigh,Loïc Lang-Lazdunski,Mieke Dewerchin,Christopher Shaw,Lieve Moons,Robert Vlietinck,Robert Vlietinck,Karen E. Morrison,Wim Robberecht,Christine Van Broeckhoven,Desire Collen,Peter M. Andersen,Peter Carmeliet +34 more
TL;DR: It is indicated that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice.
Journal ArticleDOI
A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes
Takuya Awata,Kiyoaki Inoue,Susumu Kurihara,Tomoko Ohkubo,Masaki Watanabe,Kouichi Inukai,Ikuo Inoue,Shigehiro Katayama +7 more
TL;DR: The data suggest that the C(-634)G polymorphism in the 5'UTR of the VEGF gene is a novel genetic risk factor for diabetic retinopathy.
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A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA
Takashi Kadowaki,Hiroko Kadowaki,Y Mori,Kazuyuki Tobe,Ryoichi Sakuta,Yuusuke Suzuki,Y Tanabe,Hiroshi Sakura,Takuya Awata,Yu-ichi Goto +9 more
TL;DR: Diabetes mellitus associated with the A-->G mutation at position 3243 of mitochondrial leucine transfer RNA represents a subtype of diabetes found in both patients with IDDM and patients with NIDDM in Japan.
Journal ArticleDOI
Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect
Ikuo Inoue,Sei-ichi Goto,Kasumi Mizotani,Takuya Awata,Toshiyuki Mastunaga,Shin-ichiro Kawai,Takanori Nakajima,Shigeru Hokari,Tugikazu Komoda,Shigehiro Katayama +9 more
TL;DR: In this paper, the effects of four 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (pravastatin, simvastatin and fluvastatatin) on the production and expression of inflammatory cytokines and on enzyme expression involving prostaglandin and superoxide production in cultured human umbilical vein endothelial cells (HUVEC) were examined.
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The ligands/activators for peroxisome proliferator-activated receptor α (PPARα) and PPARγ increase Cu2+, Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells
Ikuo Inoue,Sei-ichi Goto,Toshiyuki Matsunaga,Takanori Nakajima,Takuya Awata,Shigeru Hokari,Tsugikazu Komoda,Shigehiro Katayama +7 more
TL;DR: The results suggest that PPARalpha and PPARgamma gene and protein expression in endothelial cells may play a physiologic role as radical scavengers, although the details of these mechanisms remain to be established.