S
Shigeru Matsukura
Researcher at Kyoto University
Publications - 257
Citations - 18430
Shigeru Matsukura is an academic researcher from Kyoto University. The author has contributed to research in topics: Bronchoalveolar lavage & Somatostatin. The author has an hindex of 57, co-authored 257 publications receiving 17904 citations. Previous affiliations of Shigeru Matsukura include Kobe University & Nagasaki University.
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Journal ArticleDOI
A role for ghrelin in the central regulation of feeding.
Masamitsu Nakazato,Noboru Murakami,Yukari Date,Masayasu Kojima,Hisayuki Matsuo,Kenji Kangawa,Shigeru Matsukura +6 more
TL;DR: It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.
Journal ArticleDOI
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
Yukari Date,Masayasu Kojima,Hiroshi Hosoda,Akira Sawaguchi,Muhtashan S. Mondal,Tatsuo Suganuma,Shigeru Matsukura,Kenji Kangawa,Masamitsu Nakazato +8 more
TL;DR: Ghrelin probably functions not only in the control of GH secretion, but also in the regulation of diverse processes of the digestive system, and its findings provide clues to additional physiological functions of this novel gastrointestinal hormone.
Journal ArticleDOI
Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion
Tomomi Shiiya,Masamitsu Nakazato,Masanari Mizuta,Yukari Date,Muhtashan S. Mondal,Muneki Tanaka,Shin-ichi Nozoe,Hiroshi Hosoda,Kenji Kangawa,Shigeru Matsukura +9 more
TL;DR: It is demonstrated that nutritional state is a determinant of plasma ghrelin in humans andGhrelin secretion is up-regulated under conditions of negative energy balance and down-regulated in the setting of positive energy balance, suggesting the involvement of gh Relin in the regulation of feeding behavior and energy homeostasis.
Journal ArticleDOI
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.
Yukari Date,Noboru Murakami,Koji Toshinai,Shigeru Matsukura,Akira Niijima,Hisayuki Matsuo,Kenji Kangawa,Masamitsu Nakazato +7 more
TL;DR: This study indicated that the gastric vagal afferent is the major pathway conveying ghrelin's signals for starvation and GH secretion to the brain.
Journal ArticleDOI
Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration.
Koji Toshinai,Muhtashan S. Mondal,Masamitsu Nakazato,Yukari Date,Noboru Murakami,Masayasu Kojima,Kenji Kangawa,Shigeru Matsukura +7 more
TL;DR: It is reported that ghrelin mRNA expression in the gastric fundus was increased, but that gh Relin peptide content decreased after a 48-h fast, suggesting that this novel gastrointestinal hormone plays a role in the regulation of energy balance.