S
Shigeto Sato
Researcher at Juntendo University
Publications - 56
Citations - 5828
Shigeto Sato is an academic researcher from Juntendo University. The author has contributed to research in topics: Parkin & Mitochondrion. The author has an hindex of 29, co-authored 51 publications receiving 5018 citations. Previous affiliations of Shigeto Sato include Institute of Medical Science.
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Journal ArticleDOI
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
Noriyuki Matsuda,Shigeto Sato,Kahori Shiba,Kei Okatsu,Keiko Saisho,Clement A. Gautier,Yu-shin Sou,Shinji Saiki,Sumihiro Kawajiri,Fumiaki Sato,Mayumi Kimura,Masaaki Komatsu,Nobutaka Hattori,Keiji Tanaka +13 more
TL;DR: Defective mitochondrial quality control is shown to be a mechanism for neurodegeneration in some forms of Parkinson's disease.
Journal ArticleDOI
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
Kahori Shiba-Fukushima,Yuzuru Imai,Shigeharu Yoshida,Yasushi Ishihama,Tomoko Kanao,Shigeto Sato,Nobutaka Hattori +6 more
TL;DR: This study reports that Ser65 in the ubiquitin-like domain (Ubl) of Parkin is phosphorylated in a PINK1-dependent manner upon depolarisation of ΔΨm.
Journal ArticleDOI
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.
Kei Okatsu,Toshihiko Oka,Masahiro Iguchi,Kenji Imamura,Kenji Imamura,Hidetaka Kosako,Naoki Tani,Mayumi Kimura,Etsu Go,Fumika Koyano,Fumika Koyano,Manabu Funayama,Kahori Shiba-Fukushima,Shigeto Sato,Hideaki Shimizu,Yuko Fukunaga,Hisaaki Taniguchi,Masaaki Komatsu,Nobutaka Hattori,Katsuyoshi Mihara,Keiji Tanaka,Noriyuki Matsuda +21 more
TL;DR: It is reported that PINK1 is autophosphorylated following a decrease in ΔΨm and that most disease-relevant mutations hinder this event, and proposed that autoph phosphorylation of Ser228 and Ser402 in Pink1 is essential for efficient mitochondrial localization of Parkin.
Journal ArticleDOI
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
Kei Okatsu,Keiko Saisho,Midori Shimanuki,Kazuto Nakada,Hiroshi Shitara,Yu-shin Sou,Mayumi Kimura,Shigeto Sato,Nobutaka Hattori,Masaaki Komatsu,Masaaki Komatsu,Keiji Tanaka,Noriyuki Matsuda +12 more
TL;DR: It is shown that Parkin‐catalyzed K63‐linked polyubiquitylation of depolarized mitochondria resulted in ubiquitylated mitochondria being transported along microtubules to cluster in the perinuclear region, which was interfered by pathogenic mutations of Parkin.
Journal ArticleDOI
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition
Shinji Saiki,Yukiko Sasazawa,Yoko Imamichi,Sumihiro Kawajiri,Takahiro Fujimaki,Isei Tanida,Hiroki Kobayashi,Fumiaki Sato,Shigeto Sato,Kei-Ichi Ishikawa,Masaya Imoto,Nobutaka Hattori +11 more
TL;DR: It is shown that caffeine increases both the levels of microtubule-associated protein 1 light chain 3-II and the number of autophagosomes and indicates a potential new target in the regulation of apoptosis.