Shih-Hung Lin

TL;DR: The docking data showed that molecular docking is a fast and effective way to screen alpha-glucosidase and alpha-amylase inhibitors as lead compounds of natural sources isolated from medicinal plants.

TL;DR: HCD effectively interacted at the autophosphorylation site of FAK and interaction analysis indicated an H-bond with the Arg 86 and Arg 125 residues, suggesting that HCD could be a potential inhibitor ofFAK and could be used for anti-tumorigenesis and anti-metastasis treatments.

TL;DR: The results indicated that curcumin and salvianolic acid C can effectively inhibit hHMGR, and the feasibility of discovering new drug candidates through structure-based virtual screening was demonstrated.

TL;DR: Phage-display techniques are employed to screen peptide inhibitors against human HMG-CoA reductase and results indicate that the tetrapeptide PMAS inhibits hHMGR effectively and could be a lead compound to develop hypocholesterolemic agents.

TL;DR: Two of the xanthone derivatives were obtained to examine their capabilities to inhibit cell growth of both Gram-positive and Gram-negative bacterial strains, and results indicate that they may exert the inhibition effects by blocking the EI activities.