抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

This paper reviews recent experimental and theoretical progress concerning many-body phenomena in dilute, ultracold gases. It focuses on effects beyond standard weak-coupling descriptions, such as the Mott-Hubbard transition in optical lattices, strongly interacting gases in one and two dimensions, or lowest-Landau-level physics in quasi-two-dimensional gases in fast rotation. Strong correlations in fermionic gases are discussed in optical lattices or near-Feshbach resonances in the BCS-BEC crossover.

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Many-Body Physics with Ultracold Gases

The physics of quantum degenerate atomic Fermi gases in uniform as well as in harmonically trapped configurations is reviewed from a theoretical perspective. Emphasis is given to the effect of interactions that play a crucial role, bringing the gas into a superfluid phase at low temperature. In these dilute systems, interactions are characterized by a single parameter, the $s$-wave scattering length, whose value can be tuned using an external magnetic field near a broad Feshbach resonance. The BCS limit of ordinary Fermi superfluidity, the Bose-Einstein condensation (BEC) of dimers, and the unitary limit of large scattering length are important regimes exhibited by interacting Fermi gases. In particular, the BEC and the unitary regimes are characterized by a high value of the superfluid critical temperature, on the order of the Fermi temperature. Different physical properties are discussed, including the density profiles and the energy of the ground-state configurations, the momentum distribution, the fraction of condensed pairs, collective oscillations and pair-breaking effects, the expansion of the gas, the main thermodynamic properties, the behavior in the presence of optical lattices, and the signatures of superfluidity, such as the existence of quantized vortices, the quenching of the moment of inertia, and the consequences of spin polarization. Various theoretical approaches are considered, ranging from the mean-field description of the BCS-BEC crossover to nonperturbative methods based on quantum Monte Carlo techniques. A major goal of the review is to compare theoretical predictions with available experimental results.

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Theory of ultracold atomic Fermi gases

We review recent developments in the physics of ultracold atomic and molecular gases in optical lattices. Such systems are nearly perfect realisations of various kinds of Hubbard models, and as such may very well serve to mimic condensed matter phenomena. We show how these systems may be employed as quantum simulators to answer some challenging open questions of condensed matter, and even high energy physics. After a short presentation of the models and the methods of treatment of such systems, we discuss in detail, which challenges of condensed matter physics can be addressed with (i) disordered ultracold lattice gases, (ii) frustrated ultracold gases, (iii) spinor lattice gases, (iv) lattice gases in “artificial” magnetic fields, and, last but not least, (v) quantum information processing in lattice gases. For completeness, also some recent progress related to the above topics with trapped cold gases will be discussed. Motto: There are more things in heaven and earth, Horatio, Than are dreamt of in your...

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Ultracold atomic gases in optical lattices: mimicking condensed matter physics and beyond

When a neutral atom moves in a properly designed laser field, its center-of-mass motion may mimic the dynamics of a charged particle in a magnetic field, with the emergence of a Lorentz-like force. In this Colloquium the physical principles at the basis of this artificial (synthetic) magnetism are presented. The corresponding Aharonov-Bohm phase is related to the Berry's phase that emerges when the atom adiabatically follows one of the dressed states of the atom-laser interaction. Some manifestations of artificial magnetism for a cold quantum gas, in particular, in terms of vortex nucleation are discussed. The analysis is then generalized to the simulation of non-Abelian gauge potentials and some striking consequences are presented, such as the emergence of an effective spin-orbit coupling. Both the cases of bulk gases and discrete systems, where atoms are trapped in an optical lattice, are addressed.

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Colloquium: Artificial gauge potentials for neutral atoms

We report the observation of vortex pinning in rotating gaseous Bose-Einstein condensates. Vortices are pinned to columnar pinning sites created by a corotating optical lattice superimposed on the rotating Bose-Einstein condensates. We study the effects of two types of optical lattice: triangular and square. In both geometries we see an orientation locking between the vortex and the optical lattices. At sufficient intensity the square optical lattice induces a structural crossover in the vortex lattice.

Observation of vortex pinning in Bose-Einstein condensates.

We observe interlaced square vortex lattices in rotating dilute-gas spinor Bose-Einstein condensates (BEC). After preparing a hexagonal vortex lattice in a one-component BEC in an internal atomic state |1, we coherently transfer a fraction of the superfluid to a different state |2. The subsequent evolution of this pseudo-spin-1/2 superfluid towards a state of offset square lattices involves an intriguing interplay of phase-separation and -mixing dynamics, both macroscopically and on the length scale of the vortex cores, and a stage of vortex turbulence. The stability of the square structure is proved by its response to applied shear perturbations. An interference technique shows the spatial offset between the two vortex lattices. Vortex cores in either component are filled by fluid of the other component, such that the spin-1/2 order parameter forms a Skyrmion lattice.

https://arxiv.org/pdf/cond-mat/0410237.pdf

Vortex-lattice dynamics in rotating spinor Bose-Einstein condensates.

Quantum criticality emerges when a many-body system is in the proximity of a continuous phase transition that is driven by quantum fluctuations. In the quantum critical regime, exotic, yet universal properties are anticipated; ultracold atoms provide a clean system to test these predictions. We report the observation of quantum criticality with two-dimensional Bose gases in optical lattices. On the basis of in situ density measurements, we observe scaling behavior of the equation of state at low temperatures, locate the quantum critical point, and constrain the critical exponents. We observe a finite critical entropy per particle that carries a weak dependence on the atomic interaction strength. Our experiment provides a prototypical method to study quantum criticality with ultracold atoms.

https://science.sciencemag.org/content/sci/335/6072/1070.full.pdf

Observation of quantum criticality with ultracold atoms in optical lattices.

In few-body physics, Efimov states are an infinite series of three-body bound states that obey universal discrete scaling symmetry when pairwise interactions are resonantly enhanced. Despite abundant reports of Efimov states in recent cold atom experiments, direct observation of the discrete scaling symmetry remains an elusive goal. Here we report the observation of three consecutive Efimov resonances in a heteronuclear Li-Cs mixture near a broad interspecies Feshbach resonance. The positions of the resonances closely follow a geometric series 1, λ, λ². The observed scaling constant λ(exp)=4.9(4) is in good agreement with the predicted value of 4.88.

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Geometric scaling of Efimov states in a ⁶Li-¹³³Cs mixture.

We observe the proliferation of vortices in the Berezinskii-Kosterlitz-Thouless regime on a two-dimensional array of Josephson-coupled Bose-Einstein condensates. As long as the Josephson (tunneling) energy J exceeds the thermal energy T, the array is vortex free. With decreasing J/T, vortices appear in the system in ever greater numbers. We confirm thermal activation as the vortex-formation mechanism and obtain information on the size of bound vortex pairs as J/T is varied.

Shih-Kuang Tung

Papers

Observation of vortex pinning in Bose-Einstein condensates.

Vortex-lattice dynamics in rotating spinor Bose-Einstein condensates.

Observation of quantum criticality with ultracold atoms in optical lattices.

Geometric scaling of Efimov states in a ⁶Li-¹³³Cs mixture.

Vortex Proliferation in the Berezinskii-Kosterlitz-Thouless Regime on a Two-Dimensional Lattice of Bose-Einstein Condensates