S
Shih-Ming Huang
Researcher at University of Southern California
Publications - 27
Citations - 2525
Shih-Ming Huang is an academic researcher from University of Southern California. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 7, co-authored 7 publications receiving 2449 citations. Previous affiliations of Shih-Ming Huang include National Defense Medical Center.
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Journal ArticleDOI
Regulation of transcription by a protein methyltransferase.
Dagang Chen,Han Ma,Heng Hong,Stephen S. Koh,Shih-Ming Huang,Brandon T. Schurter,Dana W. Aswad,Michael R. Stallcup +7 more
TL;DR: Coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation of nuclear receptors through its association with p160 coactivators.
Journal ArticleDOI
Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins
Paul Webb,Phuong Nguyen,Jeanette Shinsako,Carol M. Anderson,Weijun Feng,Mimi P. Nguyen,Dagang Chen,Shih-Ming Huang,Sujatha Subramanian,Eileen McKinerney,Benita S. Katzenellenbogen,Michael R. Stallcup,Peter J. Kushner +12 more
TL;DR: The ability of AF-1 and AF-2 to interact with separate surfaces of the same coactivator is important for the ability of these transactivation functions to synergize.
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Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins.
Han Ma,Heng Hong,Shih-Ming Huang,Ryan A. Irvine,Paul Webb,Peter J. Kushner,Gerhard A. Coetzee,Michael R. Stallcup +7 more
TL;DR: The C-terminal region of p160 coactivators glucocorticoid receptor interacting protein 1, steroid receptor coactivator 1, and SRC-1e binds the N- terminal AF-1 activation function of the androgen receptor (AR), and p160Coactivators can thereby enhance transcriptional activation by AR.
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Synergistic, p160 Coactivator-dependent Enhancement of Estrogen Receptor Function by CARM1 and p300
TL;DR: This study explored the cooperative functional and mechanistic relationships among GRIP1, CARM1, and p300 in transient transfection assays, where they enhanced the ability of the estrogen receptor (ER) to activate transcription of a reporter gene.
Journal ArticleDOI
Mouse Zac1, a Transcriptional Coactivator and Repressor for Nuclear Receptors
TL;DR: mZac1b was a powerful coactivator for the hormone-dependent activity of nuclear receptors, including androgen, estrogen, glucocorticoid, and thyroid hormone receptors, however, with some reporter genes and in some cell lines mZ Zac1b acted as a repressor rather than a coactivators of nuclear receptor activity.