S
Shih-Yao Chen
Researcher at National Cheng Kung University
Publications - 25
Citations - 498
Shih-Yao Chen is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Arthritis & Medicine. The author has an hindex of 9, co-authored 17 publications receiving 418 citations. Previous affiliations of Shih-Yao Chen include Chung Hwa University of Medical Technology.
Papers
More filters
Journal ArticleDOI
Brief report: amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223
Yuan-Tsung Li,Shih-Yao Chen,Chrong-Reen Wang,Ming Fei Liu,Chi-Chen Lin,I-Ming Jou,Ai Li Shiau,Chao Liang Wu +7 more
TL;DR: This study is the first to demonstrate that lentivirus-mediated silencing of miR-223 can reduce disease severity of experimental arthritis.
Journal ArticleDOI
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis
I-Ming Jou,Ai Li Shiau,Shih-Yao Chen,Chrong-Reen Wang,Dar-Bin Shieh,Ching-Shan Tsai,Chao Liang Wu +6 more
TL;DR: Direct intraarticular administration of adenoviral vectors encoding TSP-1 significantly ameliorated the clinical course of CIA, accompanied by reduction of synovial hypertrophy and fewer blood vessels, and suggest that T SP-1 gene therapy may have therapeutic potential for the management of rheumatoid arthritis.
Journal ArticleDOI
Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis
Chrong-Reen Wang,Ai Li Shiau,Shih-Yao Chen,Z. S. Cheng,Y. T. Li,Che-Hsin Lee,Yi-Te Yo,Chi-Wen Lo,Yee Shin Lin,H. Y. Juan,Yuh Ling Chen,Chao Liang Wu +11 more
TL;DR: These treatments significantly reduced articular index scores, radiographic scores and histological scores, accompanied with decreased T-cell infiltrates and reduced microvessel density in the ankle joints, implicate galectin-3 and galectIn-1 as potential therapeutic targets for the treatment of RA.
Journal ArticleDOI
Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer.
Chrong-Reen Wang,Ai Li Shiau,Shih-Yao Chen,Ling-Ling Lin,Ming-Hong Tai,Gia-Shing Shieh,Pey-Ru Lin,Yi-Te Yo,Che-Hsin Lee,Shiao-Mei Kuo,Ming Fei Liu,I-Ming Jou,Chyun-Yu Yang,Po-Chuan Shen,Hwei-Ling Lee,Chao Liang Wu +15 more
TL;DR: This study is the first to demonstrate the in vivo effect of intraarticular gene delivery ofPTEN on amelioration of arthritis symptoms in rats with CIA, which involved antiangiogenic, antiproliferative, and antiinflammatory effects of PTEN via inhibition of the PI 3-kinase/Akt signaling pathway.
Journal ArticleDOI
Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene.
Shih-Yao Chen,Ai Li Shiau,Yuan-Tsung Li,Yi Shiue Lin,Che-Hsin Lee,Chao Liang Wu,Chrong-Reen Wang +6 more
TL;DR: The effects of i.a. lentiviral vector-mediated delivery of shTLR7 RNA gene on inhibition of CIA are demonstrated, and implicate the manipulation of TLR7 as a potential therapeutic strategy in RA patients.