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Shijun Zhang
Researcher at Virginia Commonwealth University
Publications - 18
Citations - 632
Shijun Zhang is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Pyran & Dopamine transporter. The author has an hindex of 14, co-authored 17 publications receiving 577 citations. Previous affiliations of Shijun Zhang include Wayne State University.
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Journal ArticleDOI
3,5-Disubstituted-thiazolidine-2,4-dione analogs as anticancer agents: design, synthesis and biological characterization.
Kai Liu,Wei Rao,Hardik I. Parikh,Qianbin Li,Tai L. Guo,Steven Grant,Glen E. Kellogg,Shijun Zhang +7 more
TL;DR: A new lead structure, 15, was identified to have improved anti-proliferative activities in U 937 cells, to induce apoptosis in U937, M12 and DU145 cancer cells, and to arrest U9 37 cells at the S-phase.
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Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent
Kai Liu,Tai L. Guo,Nitai C. Hait,Jeremy C. Allegood,Hardik I. Parikh,Wenfang Xu,Glen E. Kellogg,Steven Grant,Sarah Spiegel,Shijun Zhang +9 more
TL;DR: Biochemical assay results indicate that K145 is a selective SphK2 inhibitor, and antitumor activity of K145 was confirmed in a syngeneic mouse model by implanting murine breast cancer JC cells in BALB/c mice, thus demonstrating its in vivo efficacy as a potential lead anticancer agent.
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Dopamine transporter as target for drug development of cocaine dependence medications.
TL;DR: Progress is covered in the drug development area regarding several classes of dopamine uptake inhibitors, with an emphasis on structure-activity relationships that enhance potency and selectivity at transporters for dopamine compared with those for serotonin or norepinephrine.
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"Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional Aβ oligomerization inhibitors: design, synthesis, and biological characterization.
James A Lenhart,Xiao Ling,Ronak Gandhi,Tai L Guo,Phillip M. Gerk,Darlene H Brunzell,Shijun Zhang +6 more
TL;DR: In vitro assay results established that the length of spacer that links cholesterol and curcumin and the attaching position of the spacer onCurcumin are important structural determinants for their biological activities and strongly encourage further optimization of 14 as a new hit to develop more potent BMAOIs.
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Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma
TL;DR: The biological results showed that two hybrid compounds, 5 and 7, exhibited significantly improved lethal effects towards all three human MM cell models compared to 1 or 2 alone, as well as the combination of 1 and 2.