S
Sarah Spiegel
Researcher at Virginia Commonwealth University
Publications - 418
Citations - 52290
Sarah Spiegel is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Sphingosine & Sphingosine-1-phosphate. The author has an hindex of 120, co-authored 405 publications receiving 48937 citations. Previous affiliations of Sarah Spiegel include Georgetown University Medical Center & VCU Medical Center.
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Journal ArticleDOI
Sphingosine-1-phosphate: an enigmatic signalling lipid
Sarah Spiegel,Sheldon Milstien +1 more
TL;DR: The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions.
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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
Olivier Cuvillier,Grisha Pirianov,Burkhard Kleuser,Philip G. Vanek,Omar A. Coso,J. Silvio Gutkind,Sarah Spiegel +6 more
TL;DR: It is reported that sphingosine-1-phosphate prevents the appearance of the key features of apoptosis, namely intranucleosomal DNA fragmentation and morphological changes, which result from increased concentrations of ceramide.
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Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
Yujing Liu,Ryuichi Wada,Tadashi Yamashita,Yide Mi,Chu-Xia Deng,John P. Hobson,Hans M. Rosenfeldt,Victor E. Nava,Sung Suk Chae,Menq Jer Lee,Catherine H. Liu,Timothy Hla,Sarah Spiegel,Richard L. Proia +13 more
TL;DR: The data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development.
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Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
Menq Jer Lee,James R. Van Brocklyn,James R. Van Brocklyn,James R. Van Brocklyn,Shobha Thangada,Shobha Thangada,Shobha Thangada,Catherine H. Liu,Catherine H. Liu,Catherine H. Liu,Arthur R. Hand,Arthur R. Hand,Arthur R. Hand,Ramil Menzeleev,Ramil Menzeleev,Ramil Menzeleev,Sarah Spiegel,Sarah Spiegel,Sarah Spiegel,Timothy Hla,Timothy Hla,Timothy Hla +21 more
TL;DR: Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.
Journal ArticleDOI
Sphingolipid metabolites in inflammatory disease
Michael Maceyka,Sarah Spiegel +1 more
TL;DR: The knowledge gained in this emerging field of sphingolipid metabolism will aid in the development of new therapeutic options for inflammatory disorders.