Shin-ichi Watanabe

TL;DR: In this article, the use of unmodified aldehydes as donors in a catalytic asymmetric Mannich-type reaction was described, which provided facile access to substituted β-lactams.

TL;DR: The efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct asymmetric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of functionalized alpha- and beta-amino acids, beta-lactams, and amino alcohols.

TL;DR: The methodology developed was applied as a powerful approach toward the synthesis of enantiomerically pure functionalized α-amino acids, γ-lactones, oxime-functionalized amino acids as well as pharmacologically important targets such as (R)-cyclohexylglycine.

TL;DR: In this article, the application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account, which led to the highly diastereo and enanti-lective and concise synthesis of functionalized α- and β-amino acids, β-lactams, and amino alcohols.

TL;DR: Prodrugs of potent aldehyde analogues of the anticancer drug doxorubicin (Dox) were synthesized and were activated and decreased the proliferation of human cancer cells in in vitro proliferation assays.