S
Shingo Yamada
Researcher at Hokkaido University
Publications - 1
Citations - 258
Shingo Yamada is an academic researcher from Hokkaido University. The author has contributed to research in topics: Ubiquitin ligase & Parkin. The author has an hindex of 1, co-authored 1 publications receiving 255 citations.
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Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain
Eri Sakata,Yoshiki Yamaguchi,Eiji Kurimoto,Jun Kikuchi,Shigeyuki Yokoyama,Shingo Yamada,Hiroyuki Kawahara,Hideyoshi Yokosawa,Nobutaka Hattori,Yoshikuni Mizuno,Keiji Tanaka,Koichi Kato +11 more
TL;DR: The findings suggest that the Arg 42 mutation induces a conformational change in the Rpn10‐binding site of Ubl, resulting in impaired proteasomal binding of parkin, which could be the cause of AR‐JP.