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Shinichi Okada
Researcher at University of California, San Diego
Publications - 5
Citations - 540
Shinichi Okada is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Diabetes mellitus & Albuminuria. The author has an hindex of 5, co-authored 5 publications receiving 496 citations. Previous affiliations of Shinichi Okada include University of California, Los Angeles.
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Journal ArticleDOI
Pirfenidone Is Renoprotective in Diabetic Kidney Disease
Satish P. RamachandraRao,Yanqing Zhu,Timothy Ravasi,Tracy A. McGowan,Irene Toh,Stephen R. Dunn,Shinichi Okada,Michael A. Shaw,Kumar Sharma +8 more
TL;DR: PFD is renoprotective in diabetic kidney disease and may exert its antifibrotic effects, in part, via inhibiting RNA processing, as identified in 21 proteins unique to PFD-treated diabetic kidneys.
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Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes
TL;DR: It is concluded that fisetin lowers the elevation of MG-protein glycation that is associated with diabetes and ameliorates multiple complications of the disease.
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Obesity Related Kidney Disease
TL;DR: Weight loss, blockade of the renin angiotensin system and restoration of adipokine levels may be beneficial to ameliorate the progression of obesity related disease.
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Role of Nox2 in diabetic kidney disease
Young-Hyun You,Shinichi Okada,San Ly,Karin Jandeleit-Dahm,David Barit,Tamehachi Namikoshi,Kumar Sharma +6 more
TL;DR: It is demonstrated that lack of Nox2 does not protect against diabetic kidney disease in type 1 diabetes, despite a reduction in macrophage infiltration, and the lack of renoprotection may be due to upregulation of renal Nox4.
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TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1.
Elizabeth Morse,Jana Schroth,Young Hyun You,Donald P. Pizzo,Shinichi Okada,Satish P Ramachandrarao,Volker Vallon,Volker Vallon,Kumar Sharma,Kumar Sharma,Robyn Cunard,Robyn Cunard +11 more
TL;DR: It is demonstrated that TRB3 can inhibit basal and stimulated podocyte production of MCP-1, a chemokine that contributes to the inflammatory injury associated with diabetic nephropathy.